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Macrophages induce the inflammatory response in the pulmonary Arthus reaction through G alpha i2 activation that controls C5aR and Fc receptor cooperation.
Skokowa J, Ali SR, Felda O, Kumar V, Konrad S, Shushakova N, Schmidt RE, Piekorz RP, Nürnberg B, Spicher K, Birnbaumer L, Zwirner J, Claassens JW, Verbeek JS, van Rooijen N, Köhl J, Gessner JE. Skokowa J, et al. Among authors: gessner je. J Immunol. 2005 Mar 1;174(5):3041-50. doi: 10.4049/jimmunol.174.5.3041. J Immunol. 2005. PMID: 15728518
C5a initiates the inflammatory cascade in immune complex peritonitis.
Godau J, Heller T, Hawlisch H, Trappe M, Howells E, Best J, Zwirner J, Verbeek JS, Hogarth PM, Gerard C, Van Rooijen N, Klos A, Gessner JE, Köhl J. Godau J, et al. Among authors: gessner je. J Immunol. 2004 Sep 1;173(5):3437-45. doi: 10.4049/jimmunol.173.5.3437. J Immunol. 2004. PMID: 15322209
Defective macrophage migration in Gαi2- but not Gαi3-deficient mice.
Wiege K, Le DD, Syed SN, Ali SR, Novakovic A, Beer-Hammer S, Piekorz RP, Schmidt RE, Nürnberg B, Gessner JE. Wiege K, et al. Among authors: gessner je. J Immunol. 2012 Jul 15;189(2):980-7. doi: 10.4049/jimmunol.1200891. Epub 2012 Jun 15. J Immunol. 2012. PMID: 22706085
Gαi2 is the essential Gαi protein in immune complex-induced lung disease.
Wiege K, Ali SR, Gewecke B, Novakovic A, Konrad FM, Pexa K, Beer-Hammer S, Reutershan J, Piekorz RP, Schmidt RE, Nürnberg B, Gessner JE. Wiege K, et al. Among authors: gessner je. J Immunol. 2013 Jan 1;190(1):324-33. doi: 10.4049/jimmunol.1201398. Epub 2012 Dec 5. J Immunol. 2013. PMID: 23225882
70 results