Dunetz JR - Search Results

1

Pictet-Spengler reactions in multiphasic supercritical carbon dioxide/CO2-expanded liquid media. In situ generation of carbamates as a strategy for reactions of amines in supercritical carbon dioxide.

Dunetz JR, Ciccolini RP, Fröling M, Paap SM, Allen AJ, Holmes AB, Tester JW, Danheiser RL. Dunetz JR, et al. Chem Commun (Camb). 2005 Sep 21;(35):4465-7. doi: 10.1039/b508151c. Epub 2005 Aug 4. Chem Commun (Camb). 2005. PMID: 16136252

2

Copper-mediated N-alkynylation of carbamates, ureas, and sulfonamides. A general method for the synthesis of ynamides.

Dunetz JR, Danheiser RL. Dunetz JR, et al. Org Lett. 2003 Oct 16;5(21):4011-4. doi: 10.1021/ol035647d. Org Lett. 2003. PMID: 14535766 Free PMC article.

3

Synthesis of highly substituted indolines and indoles via intramolecular [4 + 2] cycloaddition of ynamides and conjugated enynes.

Dunetz JR, Danheiser RL. Dunetz JR, et al. J Am Chem Soc. 2005 Apr 27;127(16):5776-7. doi: 10.1021/ja051180l. J Am Chem Soc. 2005. PMID: 15839661 Free PMC article.

4

[2+2] Cycloaddition of ketenes with ynamides. A general method for the synthesis of 3-aminocyclobutenone derivatives.

Kohnen AL, Mak XY, Lam TY, Dunetz JR, Danheiser RL. Kohnen AL, et al. Among authors: dunetz jr. Tetrahedron. 2006 Apr 17;62(16):3815-3822. doi: 10.1016/j.tet.2005.11.088. Tetrahedron. 2006. PMID: 21394235 Free PMC article.

5

SYNTHESIS OF YNAMIDES BY N-ALKYNYLATION OF AMINE DERIVATIVES. PREPARATION OF N-ALLYL-N-(METHOXYCARBONYL)-1,3-DECADIYNYLAMINE.

Kohnen AL, Dunetz JR, Danheiser RL. Kohnen AL, et al. Among authors: dunetz jr. Organic Synth. 2007;84:88-101. Organic Synth. 2007. PMID: 20657723 Free PMC article. No abstract available.

6

Self-assembling porphyrin-modified peptides.

Dunetz JR, Sandstrom C, Young ER, Baker P, Van Name SA, Cathopolous T, Fairman R, de Paula JC, Akerfeldt KS. Dunetz JR, et al. Org Lett. 2005 Jun 23;7(13):2559-61. doi: 10.1021/ol050644h. Org Lett. 2005. PMID: 15957890

7

Concerning the synthesis of the tedanolide C(13)-C(23) fragment via anti-aldol reaction.

Dunetz JR, Roush WR. Dunetz JR, et al. Org Lett. 2008 May 15;10(10):2059-62. doi: 10.1021/ol800546g. Epub 2008 Apr 19. Org Lett. 2008. PMID: 18422319

8

Total syntheses of (+)-tedanolide and (+)-13-deoxytedanolide.

Dunetz JR, Julian LD, Newcom JS, Roush WR. Dunetz JR, et al. J Am Chem Soc. 2008 Dec 3;130(48):16407-16. doi: 10.1021/ja8063205. J Am Chem Soc. 2008. PMID: 18980317 Free PMC article.

9

General and scalable amide bond formation with epimerization-prone substrates using T3P and pyridine.

Dunetz JR, Xiang Y, Baldwin A, Ringling J. Dunetz JR, et al. Org Lett. 2011 Oct 7;13(19):5048-51. doi: 10.1021/ol201875q. Epub 2011 Aug 29. Org Lett. 2011. PMID: 21875100

10

Discovery and preclinical characterization of 1-methyl-3-(4-methylpyridin-3-yl)-6-(pyridin-2-ylmethoxy)-1H-pyrazolo-[3,4-b]pyrazine (PF470): a highly potent, selective, and efficacious metabotropic glutamate receptor 5 (mGluR5) negative allosteric modulator.

Zhang L, Balan G, Barreiro G, Boscoe BP, Chenard LK, Cianfrogna J, Claffey MM, Chen L, Coffman KJ, Drozda SE, Dunetz JR, Fonseca KR, Galatsis P, Grimwood S, Lazzaro JT, Mancuso JY, Miller EL, Reese MR, Rogers BN, Sakurada I, Skaddan M, Smith DL, Stepan AF, Trapa P, Tuttle JB, Verhoest PR, Walker DP, Wright AS, Zaleska MM, Zasadny K, Shaffer CL. Zhang L, et al. Among authors: dunetz jr. J Med Chem. 2014 Feb 13;57(3):861-77. doi: 10.1021/jm401622k. Epub 2014 Jan 22. J Med Chem. 2014. PMID: 24392688

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