Coffman RL - Search Results

1

Human TLR-7-, -8-, and -9-mediated induction of IFN-alpha/beta and -lambda Is IRAK-4 dependent and redundant for protective immunity to viruses.

Yang K, Puel A, Zhang S, Eidenschenk C, Ku CL, Casrouge A, Picard C, von Bernuth H, Senechal B, Plancoulaine S, Al-Hajjar S, Al-Ghonaium A, Maródi L, Davidson D, Speert D, Roifman C, Garty BZ, Ozinsky A, Barrat FJ, Coffman RL, Miller RL, Li X, Lebon P, Rodriguez-Gallego C, Chapel H, Geissmann F, Jouanguy E, Casanova JL. Yang K, et al. Among authors: coffman rl. Immunity. 2005 Nov;23(5):465-78. doi: 10.1016/j.immuni.2005.09.016. Immunity. 2005. PMID: 16286015 Free PMC article.

2

Signalling pathways leading to IFN-alpha production in human plasmacytoid dendritic cell and the possible use of agonists or antagonists of TLR7 and TLR9 in clinical indications.

Guiducci C, Coffman RL, Barrat FJ. Guiducci C, et al. Among authors: coffman rl. J Intern Med. 2009 Jan;265(1):43-57. doi: 10.1111/j.1365-2796.2008.02050.x. J Intern Med. 2009. PMID: 19093959 Free article. Review.

3

Development of TLR inhibitors for the treatment of autoimmune diseases.

Barrat FJ, Coffman RL. Barrat FJ, et al. Among authors: coffman rl. Immunol Rev. 2008 Jun;223:271-83. doi: 10.1111/j.1600-065X.2008.00630.x. Immunol Rev. 2008. PMID: 18613842 Review.

4

Therapeutic targeting of innate immunity with Toll-like receptor agonists and antagonists.

Kanzler H, Barrat FJ, Hessel EM, Coffman RL. Kanzler H, et al. Among authors: coffman rl. Nat Med. 2007 May;13(5):552-9. doi: 10.1038/nm1589. Nat Med. 2007. PMID: 17479101 Review.

5

PI3K is critical for the nuclear translocation of IRF-7 and type I IFN production by human plasmacytoid predendritic cells in response to TLR activation.

Guiducci C, Ghirelli C, Marloie-Provost MA, Matray T, Coffman RL, Liu YJ, Barrat FJ, Soumelis V. Guiducci C, et al. Among authors: coffman rl. J Exp Med. 2008 Feb 18;205(2):315-22. doi: 10.1084/jem.20070763. Epub 2008 Jan 28. J Exp Med. 2008. PMID: 18227218 Free PMC article.

6

Nucleic acids of mammalian origin can act as endogenous ligands for Toll-like receptors and may promote systemic lupus erythematosus.

Barrat FJ, Meeker T, Gregorio J, Chan JH, Uematsu S, Akira S, Chang B, Duramad O, Coffman RL. Barrat FJ, et al. Among authors: coffman rl. J Exp Med. 2005 Oct 17;202(8):1131-9. doi: 10.1084/jem.20050914. J Exp Med. 2005. PMID: 16230478 Free PMC article.

7

Inhibitors of TLR-9 act on multiple cell subsets in mouse and man in vitro and prevent death in vivo from systemic inflammation.

Duramad O, Fearon KL, Chang B, Chan JH, Gregorio J, Coffman RL, Barrat FJ. Duramad O, et al. Among authors: coffman rl. J Immunol. 2005 May 1;174(9):5193-200. doi: 10.4049/jimmunol.174.9.5193. J Immunol. 2005. PMID: 15843514

8

Autoimmune skin inflammation is dependent on plasmacytoid dendritic cell activation by nucleic acids via TLR7 and TLR9.

Guiducci C, Tripodo C, Gong M, Sangaletti S, Colombo MP, Coffman RL, Barrat FJ. Guiducci C, et al. Among authors: coffman rl. J Exp Med. 2010 Dec 20;207(13):2931-42. doi: 10.1084/jem.20101048. Epub 2010 Nov 29. J Exp Med. 2010. PMID: 21115693 Free PMC article.

9

Treatment of lupus-prone mice with a dual inhibitor of TLR7 and TLR9 leads to reduction of autoantibody production and amelioration of disease symptoms.

Barrat FJ, Meeker T, Chan JH, Guiducci C, Coffman RL. Barrat FJ, et al. Among authors: coffman rl. Eur J Immunol. 2007 Dec;37(12):3582-6. doi: 10.1002/eji.200737815. Eur J Immunol. 2007. PMID: 18034431 Free article.

10

TLR recognition of self nucleic acids hampers glucocorticoid activity in lupus.

Guiducci C, Gong M, Xu Z, Gill M, Chaussabel D, Meeker T, Chan JH, Wright T, Punaro M, Bolland S, Soumelis V, Banchereau J, Coffman RL, Pascual V, Barrat FJ. Guiducci C, et al. Among authors: coffman rl. Nature. 2010 Jun 17;465(7300):937-41. doi: 10.1038/nature09102. Nature. 2010. PMID: 20559388 Free PMC article.

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