Jakob CG - Search Results

1

Structure of MurF from Streptococcus pneumoniae co-crystallized with a small molecule inhibitor exhibits interdomain closure.

Longenecker KL, Stamper GF, Hajduk PJ, Fry EH, Jakob CG, Harlan JE, Edalji R, Bartley DM, Walter KA, Solomon LR, Holzman TF, Gu YG, Lerner CG, Beutel BA, Stoll VS. Longenecker KL, et al. Among authors: jakob cg. Protein Sci. 2005 Dec;14(12):3039-47. doi: 10.1110/ps.051604805. Protein Sci. 2005. PMID: 16322581 Free PMC article.

2

Structure-based optimization of MurF inhibitors.

Stamper GF, Longenecker KL, Fry EH, Jakob CG, Florjancic AS, Gu YG, Anderson DD, Cooper CS, Zhang T, Clark RF, Cia Y, Black-Schaefer CL, Owen McCall J, Lerner CG, Hajduk PJ, Beutel BA, Stoll VS. Stamper GF, et al. Among authors: jakob cg. Chem Biol Drug Des. 2006 Jan;67(1):58-65. doi: 10.1111/j.1747-0285.2005.00317.x. Chem Biol Drug Des. 2006. PMID: 16492149

3

Discovery of potent inhibitors of dihydroneopterin aldolase using CrystaLEAD high-throughput X-ray crystallographic screening and structure-directed lead optimization.

Sanders WJ, Nienaber VL, Lerner CG, McCall JO, Merrick SM, Swanson SJ, Harlan JE, Stoll VS, Stamper GF, Betz SF, Condroski KR, Meadows RP, Severin JM, Walter KA, Magdalinos P, Jakob CG, Wagner R, Beutel BA. Sanders WJ, et al. Among authors: jakob cg. J Med Chem. 2004 Mar 25;47(7):1709-18. doi: 10.1021/jm030497y. J Med Chem. 2004. PMID: 15027862

4

Crystal structures of DPP-IV (CD26) from rat kidney exhibit flexible accommodation of peptidase-selective inhibitors.

Longenecker KL, Stewart KD, Madar DJ, Jakob CG, Fry EH, Wilk S, Lin CW, Ballaron SJ, Stashko MA, Lubben TH, Yong H, Pireh D, Pei Z, Basha F, Wiedeman PE, von Geldern TW, Trevillyan JM, Stoll VS. Longenecker KL, et al. Among authors: jakob cg. Biochemistry. 2006 Jun 20;45(24):7474-82. doi: 10.1021/bi060184f. Biochemistry. 2006. PMID: 16768443

5

A potent erythropoietin-mimicking human antibody interacts through a novel binding site.

Liu Z, Stoll VS, Devries PJ, Jakob CG, Xie N, Simmer RL, Lacy SE, Egan DA, Harlan JE, Lesniewski RR, Reilly EB. Liu Z, et al. Among authors: jakob cg. Blood. 2007 Oct 1;110(7):2408-13. doi: 10.1182/blood-2007-04-083998. Epub 2007 Jul 9. Blood. 2007. PMID: 17620453 Free article.

6

Ligand association rates to the inner-variable-domain of a dual-variable-domain immunoglobulin are significantly impacted by linker design.

Digiammarino EL, Harlan JE, Walter KA, Ladror US, Edalji RP, Hutchins CW, Lake MR, Greischar AJ, Liu J, Ghayur T, Jakob CG. Digiammarino EL, et al. Among authors: jakob cg. MAbs. 2011 Sep-Oct;3(5):487-94. doi: 10.4161/mabs.3.5.16326. Epub 2011 Sep 1. MAbs. 2011. PMID: 21814039 Free PMC article.

7

Characterization of protein kinase A phosphorylation: multi-technique approach to phosphate mapping.

Shen J, Smith RA, Stoll VS, Edalji R, Jakob C, Walter K, Gramling E, Dorwin S, Bartley D, Gunasekera A, Yang J, Holzman T, Johnson RW. Shen J, et al. Anal Biochem. 2004 Jan 15;324(2):204-18. doi: 10.1016/j.ab.2003.09.016. Anal Biochem. 2004. PMID: 14690684

8

X-ray crystallographic structure of ABT-378 (lopinavir) bound to HIV-1 protease.

Stoll V, Qin W, Stewart KD, Jakob C, Park C, Walter K, Simmer RL, Helfrich R, Bussiere D, Kao J, Kempf D, Sham HL, Norbeck DW. Stoll V, et al. Bioorg Med Chem. 2002 Aug;10(8):2803-6. doi: 10.1016/s0968-0896(02)00051-2. Bioorg Med Chem. 2002. PMID: 12057670

9

Design, synthesis, and activity of 4-quinolone and pyridone compounds as nonthiol-containing farnesyltransferase inhibitors.

Li Q, Claiborne A, Li T, Hasvold L, Stoll VS, Muchmore S, Jakob CG, Gu W, Cohen J, Hutchins C, Frost D, Rosenberg SH, Sham HL. Li Q, et al. Among authors: jakob cg. Bioorg Med Chem Lett. 2004 Nov 1;14(21):5367-70. doi: 10.1016/j.bmcl.2004.08.012. Bioorg Med Chem Lett. 2004. PMID: 15454228

10

Design, synthesis, and biological activity of 4-[(4-cyano-2-arylbenzyloxy)-(3-methyl-3H-imidazol-4-yl)methyl]benzonitriles as potent and selective farnesyltransferase inhibitors.

Wang L, Wang GT, Wang X, Tong Y, Sullivan G, Park D, Leonard NM, Li Q, Cohen J, Gu WZ, Zhang H, Bauch JL, Jakob CG, Hutchins CW, Stoll VS, Marsh K, Rosenberg SH, Sham HL, Lin NH. Wang L, et al. Among authors: jakob cg. J Med Chem. 2004 Jan 29;47(3):612-26. doi: 10.1021/jm030434f. J Med Chem. 2004. PMID: 14736242

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