Longenecker KL - Search Results

1

Structure of MurF from Streptococcus pneumoniae co-crystallized with a small molecule inhibitor exhibits interdomain closure.

Longenecker KL, Stamper GF, Hajduk PJ, Fry EH, Jakob CG, Harlan JE, Edalji R, Bartley DM, Walter KA, Solomon LR, Holzman TF, Gu YG, Lerner CG, Beutel BA, Stoll VS. Longenecker KL, et al. Protein Sci. 2005 Dec;14(12):3039-47. doi: 10.1110/ps.051604805. Protein Sci. 2005. PMID: 16322581 Free PMC article.

2

Structure-based optimization of MurF inhibitors.

Stamper GF, Longenecker KL, Fry EH, Jakob CG, Florjancic AS, Gu YG, Anderson DD, Cooper CS, Zhang T, Clark RF, Cia Y, Black-Schaefer CL, Owen McCall J, Lerner CG, Hajduk PJ, Beutel BA, Stoll VS. Stamper GF, et al. Among authors: longenecker kl. Chem Biol Drug Des. 2006 Jan;67(1):58-65. doi: 10.1111/j.1747-0285.2005.00317.x. Chem Biol Drug Des. 2006. PMID: 16492149

3

Crystal structures of DPP-IV (CD26) from rat kidney exhibit flexible accommodation of peptidase-selective inhibitors.

Longenecker KL, Stewart KD, Madar DJ, Jakob CG, Fry EH, Wilk S, Lin CW, Ballaron SJ, Stashko MA, Lubben TH, Yong H, Pireh D, Pei Z, Basha F, Wiedeman PE, von Geldern TW, Trevillyan JM, Stoll VS. Longenecker KL, et al. Biochemistry. 2006 Jun 20;45(24):7474-82. doi: 10.1021/bi060184f. Biochemistry. 2006. PMID: 16768443

4

On-column ligand exchange for structure-based drug design: a case study with human 11β-hydroxysteroid dehydrogenase type 1.

Qin W, Judge RA, Longenecker KL, Solomon LR, Harlan JE. Qin W, et al. Among authors: longenecker kl. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 May 1;68(Pt 5):601-5. doi: 10.1107/S1744309112010172. Epub 2012 Apr 21. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012. PMID: 22691797 Free PMC article.

5

Discovery, structure-activity relationship, and pharmacological evaluation of (5-substituted-pyrrolidinyl-2-carbonyl)-2-cyanopyrrolidines as potent dipeptidyl peptidase IV inhibitors.

Pei Z, Li X, Longenecker K, von Geldern TW, Wiedeman PE, Lubben TH, Zinker BA, Stewart K, Ballaron SJ, Stashko MA, Mika AK, Beno DW, Long M, Wells H, Kempf-Grote AJ, Madar DJ, McDermott TS, Bhagavatula L, Fickes MG, Pireh D, Solomon LR, Lake MR, Edalji R, Fry EH, Sham HL, Trevillyan JM. Pei Z, et al. J Med Chem. 2006 Jun 15;49(12):3520-35. doi: 10.1021/jm051283e. J Med Chem. 2006. PMID: 16759095

6

Crystal structure and thermodynamic analysis of diagnostic mAb 106.3 complexed with BNP 5-13 (C10A).

Longenecker KL, Ruan Q, Fry EH, Saldana SC, Brophy SE, Richardson PL, Tetin SY. Longenecker KL, et al. Proteins. 2009 Aug 15;76(3):536-47. doi: 10.1002/prot.22366. Proteins. 2009. PMID: 19274732

7

Complex of human Melanotransferrin and SC57.32 Fab fragment reveals novel interdomain arrangement with ferric N-lobe and open C-lobe.

Hayashi K, Longenecker KL, Liu YL, Faust B, Prashar A, Hampl J, Stoll V, Vivona S. Hayashi K, et al. Among authors: longenecker kl. Sci Rep. 2021 Jan 12;11(1):566. doi: 10.1038/s41598-020-79090-8. Sci Rep. 2021. PMID: 33436675 Free PMC article.

8

Development of Orally Efficacious Allosteric Inhibitors of TNFα via Fragment-Based Drug Design.

Dietrich JD, Longenecker KL, Wilson NS, Goess C, Panchal SC, Swann SL, Petros AM, Hobson AD, Ihle D, Song D, Richardson P, Comess KM, Cox PB, Dombrowski A, Sarris K, Donnelly-Roberts DL, Duignan DB, Gomtsyan A, Jung P, Krueger AC, Mathieu S, McClure A, Stoll VS, Wetter J, Mankovich JA, Hajduk PJ, Vasudevan A, Stoffel RH, Sun C. Dietrich JD, et al. Among authors: longenecker kl. J Med Chem. 2021 Jan 14;64(1):417-429. doi: 10.1021/acs.jmedchem.0c01280. Epub 2020 Dec 30. J Med Chem. 2021. PMID: 33378180

9

Structure of human DPEP3 in complex with the SC-003 antibody Fab fragment reveals basis for lack of dipeptidase activity.

Hayashi K, Longenecker KL, Koenig P, Prashar A, Hampl J, Stoll V, Vivona S. Hayashi K, et al. Among authors: longenecker kl. J Struct Biol. 2020 Jul 1;211(1):107512. doi: 10.1016/j.jsb.2020.107512. Epub 2020 Apr 20. J Struct Biol. 2020. PMID: 32325220 Free article.

10

Water channel in the binding site of a high affinity anti-methotrexate antibody.

Gayda S, Longenecker KL, Manoj S, Judge RA, Saldana SC, Ruan Q, Swift KM, Tetin SY. Gayda S, et al. Among authors: longenecker kl. Biochemistry. 2014 Jun 17;53(23):3719-26. doi: 10.1021/bi5001382. Epub 2014 Jun 5. Biochemistry. 2014. PMID: 24832237

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