Conversion of the Alzheimer's beta-amyloid precursor protein (APP) Kunitz domain into a potent human neutrophil elastase inhibitor.
Sinha S, Knops J, Esch F, Moyer ED, Oltersdorf T.
Sinha S, et al.
J Biol Chem. 1991 Nov 5;266(31):21011-3.
J Biol Chem. 1991.
PMID: 1939150
Free article.
Site-specific mutagenesis techniques have been used to construct active site variants of the Kunitz-type protease inhibitor domain present in the Alzheimer's beta-amyloid precursor protein (APP-KD). Striking alteration of its protease inhibitory properties were obtained wh …
Site-specific mutagenesis techniques have been used to construct active site variants of the Kunitz-type protease inhibitor domain present i …