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Impact of HLA-B alleles, epitope binding affinity, functional avidity, and viral coinfection on the immunodominance of virus-specific CTL responses.
Bihl F, Frahm N, Di Giammarino L, Sidney J, John M, Yusim K, Woodberry T, Sango K, Hewitt HS, Henry L, Linde CH, Chisholm JV 3rd, Zaman TM, Pae E, Mallal S, Walker BD, Sette A, Korber BT, Heckerman D, Brander C. Bihl F, et al. Among authors: heckerman d. J Immunol. 2006 Apr 1;176(7):4094-101. doi: 10.4049/jimmunol.176.7.4094. J Immunol. 2006. PMID: 16547245
Control of human immunodeficiency virus replication by cytotoxic T lymphocytes targeting subdominant epitopes.
Frahm N, Kiepiela P, Adams S, Linde CH, Hewitt HS, Sango K, Feeney ME, Addo MM, Lichterfeld M, Lahaie MP, Pae E, Wurcel AG, Roach T, St John MA, Altfeld M, Marincola FM, Moore C, Mallal S, Carrington M, Heckerman D, Allen TM, Mullins JI, Korber BT, Goulder PJ, Walker BD, Brander C. Frahm N, et al. Among authors: heckerman d. Nat Immunol. 2006 Feb;7(2):173-8. doi: 10.1038/ni1281. Epub 2005 Dec 20. Nat Immunol. 2006. PMID: 16369537
Evidence of differential HLA class I-mediated viral evolution in functional and accessory/regulatory genes of HIV-1.
Brumme ZL, Brumme CJ, Heckerman D, Korber BT, Daniels M, Carlson J, Kadie C, Bhattacharya T, Chui C, Szinger J, Mo T, Hogg RS, Montaner JS, Frahm N, Brander C, Walker BD, Harrigan PR. Brumme ZL, et al. Among authors: heckerman d. PLoS Pathog. 2007 Jul;3(7):e94. doi: 10.1371/journal.ppat.0030094. PLoS Pathog. 2007. PMID: 17616974 Free PMC article.
Extensive HLA class I allele promiscuity among viral CTL epitopes.
Frahm N, Yusim K, Suscovich TJ, Adams S, Sidney J, Hraber P, Hewitt HS, Linde CH, Kavanagh DG, Woodberry T, Henry LM, Faircloth K, Listgarten J, Kadie C, Jojic N, Sango K, Brown NV, Pae E, Zaman MT, Bihl F, Khatri A, John M, Mallal S, Marincola FM, Walker BD, Sette A, Heckerman D, Korber BT, Brander C. Frahm N, et al. Among authors: heckerman d. Eur J Immunol. 2007 Sep;37(9):2419-33. doi: 10.1002/eji.200737365. Eur J Immunol. 2007. PMID: 17705138 Free PMC article.
Marked epitope- and allele-specific differences in rates of mutation in human immunodeficiency type 1 (HIV-1) Gag, Pol, and Nef cytotoxic T-lymphocyte epitopes in acute/early HIV-1 infection.
Brumme ZL, Brumme CJ, Carlson J, Streeck H, John M, Eichbaum Q, Block BL, Baker B, Kadie C, Markowitz M, Jessen H, Kelleher AD, Rosenberg E, Kaldor J, Yuki Y, Carrington M, Allen TM, Mallal S, Altfeld M, Heckerman D, Walker BD. Brumme ZL, et al. Among authors: heckerman d. J Virol. 2008 Sep;82(18):9216-27. doi: 10.1128/JVI.01041-08. Epub 2008 Jul 9. J Virol. 2008. PMID: 18614631 Free PMC article.
Protective HLA class I alleles that restrict acute-phase CD8+ T-cell responses are associated with viral escape mutations located in highly conserved regions of human immunodeficiency virus type 1.
Wang YE, Li B, Carlson JM, Streeck H, Gladden AD, Goodman R, Schneidewind A, Power KA, Toth I, Frahm N, Alter G, Brander C, Carrington M, Walker BD, Altfeld M, Heckerman D, Allen TM. Wang YE, et al. Among authors: heckerman d. J Virol. 2009 Feb;83(4):1845-55. doi: 10.1128/JVI.01061-08. Epub 2008 Nov 26. J Virol. 2009. PMID: 19036810 Free PMC article.
HLA-associated immune escape pathways in HIV-1 subtype B Gag, Pol and Nef proteins.
Brumme ZL, John M, Carlson JM, Brumme CJ, Chan D, Brockman MA, Swenson LC, Tao I, Szeto S, Rosato P, Sela J, Kadie CM, Frahm N, Brander C, Haas DW, Riddler SA, Haubrich R, Walker BD, Harrigan PR, Heckerman D, Mallal S. Brumme ZL, et al. Among authors: heckerman d. PLoS One. 2009 Aug 19;4(8):e6687. doi: 10.1371/journal.pone.0006687. PLoS One. 2009. PMID: 19690614 Free PMC article.
126 results