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Heparins increase endothelial nitric oxide bioavailability by liberating vessel-immobilized myeloperoxidase.
Baldus S, Rudolph V, Roiss M, Ito WD, Rudolph TK, Eiserich JP, Sydow K, Lau D, Szöcs K, Klinke A, Kubala L, Berglund L, Schrepfer S, Deuse T, Haddad M, Risius T, Klemm H, Reichenspurner HC, Meinertz T, Heitzer T. Baldus S, et al. Among authors: meinertz t. Circulation. 2006 Apr 18;113(15):1871-8. doi: 10.1161/CIRCULATIONAHA.105.590083. Epub 2006 Apr 10. Circulation. 2006. PMID: 16606792
Myeloperoxidase serum levels predict risk in patients with acute coronary syndromes.
Baldus S, Heeschen C, Meinertz T, Zeiher AM, Eiserich JP, Münzel T, Simoons ML, Hamm CW; CAPTURE Investigators. Baldus S, et al. Among authors: meinertz t. Circulation. 2003 Sep 23;108(12):1440-5. doi: 10.1161/01.CIR.0000090690.67322.51. Epub 2003 Sep 2. Circulation. 2003. PMID: 12952835 Free article.
Clopidogrel improves systemic endothelial nitric oxide bioavailability in patients with coronary artery disease: evidence for antioxidant and antiinflammatory effects.
Heitzer T, Rudolph V, Schwedhelm E, Karstens M, Sydow K, Ortak M, Tschentscher P, Meinertz T, Böger R, Baldus S. Heitzer T, et al. Among authors: meinertz t. Arterioscler Thromb Vasc Biol. 2006 Jul;26(7):1648-52. doi: 10.1161/01.ATV.0000225288.74170.dc. Epub 2006 May 4. Arterioscler Thromb Vasc Biol. 2006. PMID: 16675725 Clinical Trial.
Bivalirudin decreases NO bioavailability by vascular immobilization of myeloperoxidase.
Rudolph V, Rudolph TK, Schopfer FJ, Bonacci G, Lau D, Szöcs K, Klinke A, Meinertz T, Freeman BA, Baldus S. Rudolph V, et al. Among authors: meinertz t. J Pharmacol Exp Ther. 2008 Nov;327(2):324-31. doi: 10.1124/jpet.108.142414. Epub 2008 Aug 13. J Pharmacol Exp Ther. 2008. PMID: 18701766 Free PMC article. Clinical Trial.
Pathogenic cycle between the endogenous nitric oxide synthase inhibitor asymmetrical dimethylarginine and the leukocyte-derived hemoprotein myeloperoxidase.
von Leitner EC, Klinke A, Atzler D, Slocum JL, Lund N, Kielstein JT, Maas R, Schmidt-Haupt R, Pekarova M, Hellwinkel O, Tsikas D, D'Alecy LG, Lau D, Willems S, Kubala L, Ehmke H, Meinertz T, Blankenberg S, Schwedhelm E, Gadegbeku CA, Böger RH, Baldus S, Sydow K. von Leitner EC, et al. Among authors: meinertz t. Circulation. 2011 Dec 13;124(24):2735-45. doi: 10.1161/CIRCULATIONAHA.111.060541. Epub 2011 Nov 14. Circulation. 2011. PMID: 22082678
Myeloperoxidase mediates neutrophil activation by association with CD11b/CD18 integrins.
Lau D, Mollnau H, Eiserich JP, Freeman BA, Daiber A, Gehling UM, Brümmer J, Rudolph V, Münzel T, Heitzer T, Meinertz T, Baldus S. Lau D, et al. Among authors: meinertz t. Proc Natl Acad Sci U S A. 2005 Jan 11;102(2):431-6. doi: 10.1073/pnas.0405193102. Epub 2004 Dec 29. Proc Natl Acad Sci U S A. 2005. PMID: 15625114 Free PMC article.
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