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The K65R reverse transcriptase mutation in HIV-1 reverses the excision phenotype of zidovudine resistance mutations.
Antivir Ther. 2006;11(2):155-63. doi: 10.1177/135965350601100209.
Antivir Ther. 2006.
PMID: 16640096
A combination of decreased NRTI incorporation and decreased excision determines the resistance profile of HIV-1 K65R RT.
White KL, Margot NA, Ly JK, Chen JM, Ray AS, Pavelko M, Wang R, McDermott M, Swaminathan S, Miller MD.
White KL, et al. Among authors: ly jk.
AIDS. 2005 Nov 4;19(16):1751-60. doi: 10.1097/01.aids.0000189851.21441.f1.
AIDS. 2005.
PMID: 16227782
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The balance between NRTI discrimination and excision drives the susceptibility of HIV-1 RT mutants K65R, M184V and K65r+M184V.
Ly JK, Margot NA, MacArthur HL, Hung M, Miller MD, White KL.
Ly JK, et al.
Antivir Chem Chemother. 2007;18(6):307-16. doi: 10.1177/095632020701800603.
Antivir Chem Chemother. 2007.
PMID: 18320935
Free article.
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The A62V and S68G mutations in HIV-1 reverse transcriptase partially restore the replication defect associated with the K65R mutation.
Svarovskaia ES, Feng JY, Margot NA, Myrick F, Goodman D, Ly JK, White KL, Kutty N, Wang R, Borroto-Esoda K, Miller MD.
Svarovskaia ES, et al. Among authors: ly jk.
J Acquir Immune Defic Syndr. 2008 Aug 1;48(4):428-36. doi: 10.1097/QAI.0b013e31817bbe93.
J Acquir Immune Defic Syndr. 2008.
PMID: 18614922
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The triple combination of tenofovir, emtricitabine and efavirenz shows synergistic anti-HIV-1 activity in vitro: a mechanism of action study.
Feng JY, Ly JK, Myrick F, Goodman D, White KL, Svarovskaia ES, Borroto-Esoda K, Miller MD.
Feng JY, et al. Among authors: ly jk.
Retrovirology. 2009 May 13;6:44. doi: 10.1186/1742-4690-6-44.
Retrovirology. 2009.
PMID: 19439089
Free PMC article.
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Effects of the translocation status of human immunodeficiency virus type 1 reverse transcriptase on the efficiency of excision of tenofovir.
Marchand B, White KL, Ly JK, Margot NA, Wang R, McDermott M, Miller MD, Götte M.
Marchand B, et al. Among authors: ly jk.
Antimicrob Agents Chemother. 2007 Aug;51(8):2911-9. doi: 10.1128/AAC.00314-07. Epub 2007 May 21.
Antimicrob Agents Chemother. 2007.
PMID: 17517852
Free PMC article.
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