McDermott MJ - Search Results

1

The K65R reverse transcriptase mutation in HIV-1 reverses the excision phenotype of zidovudine resistance mutations.

White KL, Chen JM, Feng JY, Margot NA, Ly JK, Ray AS, Macarthur HL, McDermott MJ, Swaminathan S, Miller MD. White KL, et al. Among authors: mcdermott mj. Antivir Ther. 2006;11(2):155-63. doi: 10.1177/135965350601100209. Antivir Ther. 2006. PMID: 16640096

2

A combination of decreased NRTI incorporation and decreased excision determines the resistance profile of HIV-1 K65R RT.

White KL, Margot NA, Ly JK, Chen JM, Ray AS, Pavelko M, Wang R, McDermott M, Swaminathan S, Miller MD. White KL, et al. AIDS. 2005 Nov 4;19(16):1751-60. doi: 10.1097/01.aids.0000189851.21441.f1. AIDS. 2005. PMID: 16227782

3

Suppression of HIV-1 protease inhibitor resistance by phosphonate-mediated solvent anchoring.

Cihlar T, He GX, Liu X, Chen JM, Hatada M, Swaminathan S, McDermott MJ, Yang ZY, Mulato AS, Chen X, Leavitt SA, Stray KM, Lee WA. Cihlar T, et al. Among authors: mcdermott mj. J Mol Biol. 2006 Oct 27;363(3):635-47. doi: 10.1016/j.jmb.2006.07.073. Epub 2006 Aug 2. J Mol Biol. 2006. PMID: 16979654

4

Effects of the translocation status of human immunodeficiency virus type 1 reverse transcriptase on the efficiency of excision of tenofovir.

Marchand B, White KL, Ly JK, Margot NA, Wang R, McDermott M, Miller MD, Götte M. Marchand B, et al. Antimicrob Agents Chemother. 2007 Aug;51(8):2911-9. doi: 10.1128/AAC.00314-07. Epub 2007 May 21. Antimicrob Agents Chemother. 2007. PMID: 17517852 Free PMC article.

5

Discovery of GS-9131: Design, synthesis and optimization of amidate prodrugs of the novel nucleoside phosphonate HIV reverse transcriptase (RT) inhibitor GS-9148.

Mackman RL, Ray AS, Hui HC, Zhang L, Birkus G, Boojamra CG, Desai MC, Douglas JL, Gao Y, Grant D, Laflamme G, Lin KY, Markevitch DY, Mishra R, McDermott M, Pakdaman R, Petrakovsky OV, Vela JE, Cihlar T. Mackman RL, et al. Bioorg Med Chem. 2010 May 15;18(10):3606-17. doi: 10.1016/j.bmc.2010.03.041. Epub 2010 Mar 27. Bioorg Med Chem. 2010. PMID: 20409721

6

HIV-1 integrase preassembled on donor DNA is refractory to activity stimulation by LEDGF/p75.

Yu F, Jones GS, Hung M, Wagner AH, MacArthur HL, Liu X, Leavitt S, McDermott MJ, Tsiang M. Yu F, et al. Among authors: mcdermott mj. Biochemistry. 2007 Mar 13;46(10):2899-908. doi: 10.1021/bi602387u. Epub 2007 Feb 14. Biochemistry. 2007. PMID: 17298035

7

Cathepsin A is the major hydrolase catalyzing the intracellular hydrolysis of the antiretroviral nucleotide phosphonoamidate prodrugs GS-7340 and GS-9131.

Birkus G, Wang R, Liu X, Kutty N, MacArthur H, Cihlar T, Gibbs C, Swaminathan S, Lee W, McDermott M. Birkus G, et al. Antimicrob Agents Chemother. 2007 Feb;51(2):543-50. doi: 10.1128/AAC.00968-06. Epub 2006 Dec 4. Antimicrob Agents Chemother. 2007. PMID: 17145787 Free PMC article.

8

Activation of 9-[(R)-2-[[(S)-[[(S)-1-(Isopropoxycarbonyl)ethyl]amino] phenoxyphosphinyl]-methoxy]propyl]adenine (GS-7340) and other tenofovir phosphonoamidate prodrugs by human proteases.

Birkus G, Kutty N, He GX, Mulato A, Lee W, McDermott M, Cihlar T. Birkus G, et al. Mol Pharmacol. 2008 Jul;74(1):92-100. doi: 10.1124/mol.108.045526. Epub 2008 Apr 22. Mol Pharmacol. 2008. PMID: 18430788

9

Role of cathepsin A and lysosomes in the intracellular activation of novel antipapillomavirus agent GS-9191.

Birkus G, Kutty N, Frey CR, Shribata R, Chou T, Wagner C, McDermott M, Cihlar T. Birkus G, et al. Antimicrob Agents Chemother. 2011 May;55(5):2166-73. doi: 10.1128/AAC.01603-10. Epub 2011 Mar 7. Antimicrob Agents Chemother. 2011. PMID: 21383096 Free PMC article.

10

Mechanistically Guided Materials Chemistry: Synthesis of Ternary Nitrides, CaZrN₂ and CaHfN₂.

Rom CL, Novick A, McDermott MJ, Yakovenko AA, Gallawa JR, Tran GT, Asebiah DC, Storck EN, McBride BC, Miller RC, Prieto AL, Persson KA, Toberer E, Stevanović V, Zakutayev A, Neilson JR. Rom CL, et al. Among authors: mcdermott mj. J Am Chem Soc. 2024 Feb 14;146(6):4001-4012. doi: 10.1021/jacs.3c12114. Epub 2024 Jan 30. J Am Chem Soc. 2024. PMID: 38291812

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