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Targeting C-reactive protein for the treatment of cardiovascular disease.
Pepys MB, Hirschfield GM, Tennent GA, Gallimore JR, Kahan MC, Bellotti V, Hawkins PN, Myers RM, Smith MD, Polara A, Cobb AJ, Ley SV, Aquilina JA, Robinson CV, Sharif I, Gray GA, Sabin CA, Jenvey MC, Kolstoe SE, Thompson D, Wood SP. Pepys MB, et al. Among authors: kolstoe se. Nature. 2006 Apr 27;440(7088):1217-21. doi: 10.1038/nature04672. Nature. 2006. PMID: 16642000
Targeted pharmacological depletion of serum amyloid P component for treatment of human amyloidosis.
Pepys MB, Herbert J, Hutchinson WL, Tennent GA, Lachmann HJ, Gallimore JR, Lovat LB, Bartfai T, Alanine A, Hertel C, Hoffmann T, Jakob-Roetne R, Norcross RD, Kemp JA, Yamamura K, Suzuki M, Taylor GW, Murray S, Thompson D, Purvis A, Kolstoe S, Wood SP, Hawkins PN. Pepys MB, et al. Nature. 2002 May 16;417(6886):254-9. doi: 10.1038/417254a. Nature. 2002. PMID: 12015594
Bifunctional crosslinking ligands for transthyretin.
Mangione PP, Deroo S, Ellmerich S, Bellotti V, Kolstoe S, Wood SP, Robinson CV, Smith MD, Tennent GA, Broadbridge RJ, Council CE, Thurston JR, Steadman VA, Vong AK, Swain CJ, Pepys MB, Taylor GW. Mangione PP, et al. Open Biol. 2015 Sep;5(9):150105. doi: 10.1098/rsob.150105. Open Biol. 2015. PMID: 26400472 Free PMC article.
Trapping of palindromic ligands within native transthyretin prevents amyloid formation.
Kolstoe SE, Mangione PP, Bellotti V, Taylor GW, Tennent GA, Deroo S, Morrison AJ, Cobb AJ, Coyne A, McCammon MG, Warner TD, Mitchell J, Gill R, Smith MD, Ley SV, Robinson CV, Wood SP, Pepys MB. Kolstoe SE, et al. Proc Natl Acad Sci U S A. 2010 Nov 23;107(47):20483-8. doi: 10.1073/pnas.1008255107. Epub 2010 Nov 8. Proc Natl Acad Sci U S A. 2010. PMID: 21059958 Free PMC article.
Interaction of serum amyloid P component with hexanoyl bis(D-proline) (CPHPC).
Kolstoe SE, Jenvey MC, Purvis A, Light ME, Thompson D, Hughes P, Pepys MB, Wood SP. Kolstoe SE, et al. Acta Crystallogr D Biol Crystallogr. 2014 Aug;70(Pt 8):2232-40. doi: 10.1107/S1399004714013455. Epub 2014 Jul 25. Acta Crystallogr D Biol Crystallogr. 2014. PMID: 25084341 Free PMC article.
Drug targets for amyloidosis.
Kolstoe SE, Wood SP. Kolstoe SE, et al. Biochem Soc Trans. 2010 Apr;38(2):466-70. doi: 10.1042/BST0380466. Biochem Soc Trans. 2010. PMID: 20298204 Review.
37 results