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Targeting C-reactive protein for the treatment of cardiovascular disease.
Pepys MB, Hirschfield GM, Tennent GA, Gallimore JR, Kahan MC, Bellotti V, Hawkins PN, Myers RM, Smith MD, Polara A, Cobb AJ, Ley SV, Aquilina JA, Robinson CV, Sharif I, Gray GA, Sabin CA, Jenvey MC, Kolstoe SE, Thompson D, Wood SP. Pepys MB, et al. Among authors: ley sv. Nature. 2006 Apr 27;440(7088):1217-21. doi: 10.1038/nature04672. Nature. 2006. PMID: 16642000
Trapping of palindromic ligands within native transthyretin prevents amyloid formation.
Kolstoe SE, Mangione PP, Bellotti V, Taylor GW, Tennent GA, Deroo S, Morrison AJ, Cobb AJ, Coyne A, McCammon MG, Warner TD, Mitchell J, Gill R, Smith MD, Ley SV, Robinson CV, Wood SP, Pepys MB. Kolstoe SE, et al. Among authors: ley sv. Proc Natl Acad Sci U S A. 2010 Nov 23;107(47):20483-8. doi: 10.1073/pnas.1008255107. Epub 2010 Nov 8. Proc Natl Acad Sci U S A. 2010. PMID: 21059958 Free PMC article.
A fascination with 1,2-diacetals.
Ley SV, Polara A. Ley SV, et al. J Org Chem. 2007 Aug 3;72(16):5943-59. doi: 10.1021/jo0703451. Epub 2007 Apr 13. J Org Chem. 2007. PMID: 17430000
Organic synthesis: march of the machines.
Ley SV, Fitzpatrick DE, Ingham RJ, Myers RM. Ley SV, et al. Angew Chem Int Ed Engl. 2015 Mar 9;54(11):3449-64. doi: 10.1002/anie.201410744. Epub 2015 Jan 13. Angew Chem Int Ed Engl. 2015. PMID: 25586940
Synthesis of the thapsigargins.
Ley SV, Antonello A, Balskus EP, Booth DT, Christensen SB, Cleator E, Gold H, Högenauer K, Hünger U, Myers RM, Oliver SF, Simic O, Smith MD, Søhoel H, Woolford AJ. Ley SV, et al. Proc Natl Acad Sci U S A. 2004 Aug 17;101(33):12073-8. doi: 10.1073/pnas.0403300101. Epub 2004 Jun 28. Proc Natl Acad Sci U S A. 2004. PMID: 15226504 Free PMC article.
292 results