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Phosphorylation of Ser-129 is the dominant pathological modification of alpha-synuclein in familial and sporadic Lewy body disease.
Anderson JP, Walker DE, Goldstein JM, de Laat R, Banducci K, Caccavello RJ, Barbour R, Huang J, Kling K, Lee M, Diep L, Keim PS, Shen X, Chataway T, Schlossmacher MG, Seubert P, Schenk D, Sinha S, Gai WP, Chilcote TJ. Anderson JP, et al. Among authors: seubert p. J Biol Chem. 2006 Oct 6;281(40):29739-52. doi: 10.1074/jbc.M600933200. Epub 2006 Jul 17. J Biol Chem. 2006. PMID: 16847063 Free article.
Red blood cells are the major source of alpha-synuclein in blood.
Barbour R, Kling K, Anderson JP, Banducci K, Cole T, Diep L, Fox M, Goldstein JM, Soriano F, Seubert P, Chilcote TJ. Barbour R, et al. Among authors: seubert p. Neurodegener Dis. 2008;5(2):55-9. doi: 10.1159/000112832. Epub 2008 Jan 4. Neurodegener Dis. 2008. PMID: 18182779
Structural correlates of antibodies associated with acute reversal of amyloid beta-related behavioral deficits in a mouse model of Alzheimer disease.
Basi GS, Feinberg H, Oshidari F, Anderson J, Barbour R, Baker J, Comery TA, Diep L, Gill D, Johnson-Wood K, Goel A, Grantcharova K, Lee M, Li J, Partridge A, Griswold-Prenner I, Piot N, Walker D, Widom A, Pangalos MN, Seubert P, Jacobsen JS, Schenk D, Weis WI. Basi GS, et al. Among authors: seubert p. J Biol Chem. 2010 Jan 29;285(5):3417-27. doi: 10.1074/jbc.M109.045187. Epub 2009 Nov 18. J Biol Chem. 2010. PMID: 19923222 Free PMC article.
Passive immunization reduces behavioral and neuropathological deficits in an alpha-synuclein transgenic model of Lewy body disease.
Masliah E, Rockenstein E, Mante M, Crews L, Spencer B, Adame A, Patrick C, Trejo M, Ubhi K, Rohn TT, Mueller-Steiner S, Seubert P, Barbour R, McConlogue L, Buttini M, Games D, Schenk D. Masliah E, et al. Among authors: seubert p. PLoS One. 2011 Apr 29;6(4):e19338. doi: 10.1371/journal.pone.0019338. PLoS One. 2011. PMID: 21559417 Free PMC article.
Axonopathy in an α-synuclein transgenic model of Lewy body disease is associated with extensive accumulation of C-terminal-truncated α-synuclein.
Games D, Seubert P, Rockenstein E, Patrick C, Trejo M, Ubhi K, Ettle B, Ghassemiam M, Barbour R, Schenk D, Nuber S, Masliah E. Games D, et al. Among authors: seubert p. Am J Pathol. 2013 Mar;182(3):940-53. doi: 10.1016/j.ajpath.2012.11.018. Epub 2013 Jan 9. Am J Pathol. 2013. PMID: 23313024 Free PMC article.
Reducing C-terminal-truncated alpha-synuclein by immunotherapy attenuates neurodegeneration and propagation in Parkinson's disease-like models.
Games D, Valera E, Spencer B, Rockenstein E, Mante M, Adame A, Patrick C, Ubhi K, Nuber S, Sacayon P, Zago W, Seubert P, Barbour R, Schenk D, Masliah E. Games D, et al. Among authors: seubert p. J Neurosci. 2014 Jul 9;34(28):9441-54. doi: 10.1523/JNEUROSCI.5314-13.2014. J Neurosci. 2014. PMID: 25009275 Free PMC article.
Purification and cloning of amyloid precursor protein beta-secretase from human brain.
Sinha S, Anderson JP, Barbour R, Basi GS, Caccavello R, Davis D, Doan M, Dovey HF, Frigon N, Hong J, Jacobson-Croak K, Jewett N, Keim P, Knops J, Lieberburg I, Power M, Tan H, Tatsuno G, Tung J, Schenk D, Seubert P, Suomensaari SM, Wang S, Walker D, Zhao J, McConlogue L, John V. Sinha S, et al. Among authors: seubert p. Nature. 1999 Dec 2;402(6761):537-40. doi: 10.1038/990114. Nature. 1999. PMID: 10591214
98 results