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CTLA-4 blockade decreases TGF-beta, IDO, and viral RNA expression in tissues of SIVmac251-infected macaques.
Hryniewicz A, Boasso A, Edghill-Smith Y, Vaccari M, Fuchs D, Venzon D, Nacsa J, Betts MR, Tsai WP, Heraud JM, Beer B, Blanset D, Chougnet C, Lowy I, Shearer GM, Franchini G. Hryniewicz A, et al. Among authors: lowy i. Blood. 2006 Dec 1;108(12):3834-42. doi: 10.1182/blood-2006-04-010637. Epub 2006 Aug 8. Blood. 2006. PMID: 16896154 Free PMC article.
Immune activation driven by CTLA-4 blockade augments viral replication at mucosal sites in simian immunodeficiency virus infection.
Cecchinato V, Tryniszewska E, Ma ZM, Vaccari M, Boasso A, Tsai WP, Petrovas C, Fuchs D, Heraud JM, Venzon D, Shearer GM, Koup RA, Lowy I, Miller CJ, Franchini G. Cecchinato V, et al. Among authors: lowy i. J Immunol. 2008 Apr 15;180(8):5439-47. doi: 10.4049/jimmunol.180.8.5439. J Immunol. 2008. PMID: 18390726 Free PMC article.
A pilot study of CTLA-4 blockade after cancer vaccine failure in patients with advanced malignancy.
O'Mahony D, Morris JC, Quinn C, Gao W, Wilson WH, Gause B, Pittaluga S, Neelapu S, Brown M, Fleisher TA, Gulley JL, Schlom J, Nussenblatt R, Albert P, Davis TA, Lowy I, Petrus M, Waldmann TA, Janik JE. O'Mahony D, et al. Among authors: lowy i. Clin Cancer Res. 2007 Feb 1;13(3):958-64. doi: 10.1158/1078-0432.CCR-06-1974. Clin Cancer Res. 2007. PMID: 17289891
CTLA-4 blockade following relapse of malignancy after allogeneic stem cell transplantation is associated with T cell activation but not with increased levels of T regulatory cells.
Zhou J, Bashey A, Zhong R, Corringham S, Messer K, Pu M, Ma W, Chut T, Soiffer R, Mitrovich RC, Lowy I, Ball ED. Zhou J, et al. Among authors: lowy i. Biol Blood Marrow Transplant. 2011 May;17(5):682-92. doi: 10.1016/j.bbmt.2010.08.005. Epub 2010 Aug 14. Biol Blood Marrow Transplant. 2011. PMID: 20713164 Free PMC article. Clinical Trial.
Phase I study of ipilimumab, an anti-CTLA-4 monoclonal antibody, in patients with relapsed and refractory B-cell non-Hodgkin lymphoma.
Ansell SM, Hurvitz SA, Koenig PA, LaPlant BR, Kabat BF, Fernando D, Habermann TM, Inwards DJ, Verma M, Yamada R, Erlichman C, Lowy I, Timmerman JM. Ansell SM, et al. Among authors: lowy i. Clin Cancer Res. 2009 Oct 15;15(20):6446-53. doi: 10.1158/1078-0432.CCR-09-1339. Epub 2009 Oct 6. Clin Cancer Res. 2009. PMID: 19808874 Free PMC article. Clinical Trial.
168 results