Bieschke J - Search Results

1

Opposing activities protect against age-onset proteotoxicity.

Cohen E, Bieschke J, Perciavalle RM, Kelly JW, Dillin A. Cohen E, et al. Among authors: bieschke j. Science. 2006 Sep 15;313(5793):1604-10. doi: 10.1126/science.1124646. Epub 2006 Aug 10. Science. 2006. PMID: 16902091

2

A kinetic assessment of the C. elegans amyloid disaggregation activity enables uncoupling of disassembly and proteolysis.

Bieschke J, Cohen E, Murray A, Dillin A, Kelly JW. Bieschke J, et al. Protein Sci. 2009 Nov;18(11):2231-41. doi: 10.1002/pro.234. Protein Sci. 2009. PMID: 19701939 Free PMC article.

3

Oxidative metabolites accelerate Alzheimer's amyloidogenesis by a two-step mechanism, eliminating the requirement for nucleation.

Bieschke J, Zhang Q, Powers ET, Lerner RA, Kelly JW. Bieschke J, et al. Biochemistry. 2005 Apr 5;44(13):4977-83. doi: 10.1021/bi0501030. Biochemistry. 2005. PMID: 15794636

4

E-olefin dipeptide isostere incorporation into a polypeptide backbone enables hydrogen bond perturbation: probing the requirements for Alzheimer's amyloidogenesis.

Fu Y, Bieschke J, Kelly JW. Fu Y, et al. Among authors: bieschke j. J Am Chem Soc. 2005 Nov 9;127(44):15366-7. doi: 10.1021/ja0551382. J Am Chem Soc. 2005. PMID: 16262389

5

Small molecule oxidation products trigger disease-associated protein misfolding.

Bieschke J, Zhang Q, Bosco DA, Lerner RA, Powers ET, Wentworth P Jr, Kelly JW. Bieschke J, et al. Acc Chem Res. 2006 Sep;39(9):611-9. doi: 10.1021/ar0500766. Acc Chem Res. 2006. PMID: 16981677 Review.

6

The oxidative stress metabolite 4-hydroxynonenal promotes Alzheimer protofibril formation.

Siegel SJ, Bieschke J, Powers ET, Kelly JW. Siegel SJ, et al. Among authors: bieschke j. Biochemistry. 2007 Feb 13;46(6):1503-10. doi: 10.1021/bi061853s. Biochemistry. 2007. PMID: 17279615 Free PMC article.

7

Alzheimer's Abeta peptides containing an isostructural backbone mutation afford distinct aggregate morphologies but analogous cytotoxicity. Evidence for a common low-abundance toxic structure(s)?

Bieschke J, Siegel SJ, Fu Y, Kelly JW. Bieschke J, et al. Biochemistry. 2008 Jan 8;47(1):50-9. doi: 10.1021/bi701757v. Epub 2007 Dec 14. Biochemistry. 2008. PMID: 18078350

8

Surface adsorption considerations when working with amyloid fibrils in multiwell plates and Eppendorf tubes.

Murray AN, Palhano FL, Bieschke J, Kelly JW. Murray AN, et al. Among authors: bieschke j. Protein Sci. 2013 Nov;22(11):1531-41. doi: 10.1002/pro.2339. Epub 2013 Sep 30. Protein Sci. 2013. PMID: 23963844 Free PMC article.

9

Metabolite-initiated protein misfolding may trigger Alzheimer's disease.

Zhang Q, Powers ET, Nieva J, Huff ME, Dendle MA, Bieschke J, Glabe CG, Eschenmoser A, Wentworth P Jr, Lerner RA, Kelly JW. Zhang Q, et al. Among authors: bieschke j. Proc Natl Acad Sci U S A. 2004 Apr 6;101(14):4752-7. doi: 10.1073/pnas.0400924101. Epub 2004 Mar 19. Proc Natl Acad Sci U S A. 2004. PMID: 15034169 Free PMC article.

10

Structure-function-folding relationship in a WW domain.

Jäger M, Zhang Y, Bieschke J, Nguyen H, Dendle M, Bowman ME, Noel JP, Gruebele M, Kelly JW. Jäger M, et al. Among authors: bieschke j. Proc Natl Acad Sci U S A. 2006 Jul 11;103(28):10648-53. doi: 10.1073/pnas.0600511103. Epub 2006 Jun 28. Proc Natl Acad Sci U S A. 2006. PMID: 16807295 Free PMC article.

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