Schrader W - Search Results

1

An orally active selective androgen receptor modulator is efficacious on bone, muscle, and sex function with reduced impact on prostate.

Miner JN, Chang W, Chapman MS, Finn PD, Hong MH, López FJ, Marschke KB, Rosen J, Schrader W, Turner R, van Oeveren A, Viveros H, Zhi L, Negro-Vilar A. Miner JN, et al. Among authors: schrader w. Endocrinology. 2007 Jan;148(1):363-73. doi: 10.1210/en.2006-0793. Epub 2006 Oct 5. Endocrinology. 2007. PMID: 17023534

2

Discovery of 6-N,N-bis(2,2,2-trifluoroethyl)amino- 4-trifluoromethylquinolin-2(1H)-one as a novel selective androgen receptor modulator.

van Oeveren A, Motamedi M, Mani NS, Marschke KB, López FJ, Schrader WT, Negro-Vilar A, Zhi L. van Oeveren A, et al. J Med Chem. 2006 Oct 19;49(21):6143-6. doi: 10.1021/jm060792t. J Med Chem. 2006. PMID: 17034117

3

Novel series of potent, nonsteroidal, selective androgen receptor modulators based on 7H-[1,4]oxazino[3,2-g]quinolin-7-ones.

Higuchi RI, Arienti KL, López FJ, Mani NS, Mais DE, Caferro TR, Long YO, Jones TK, Edwards JP, Zhi L, Schrader WT, Negro-Vilar A, Marschke KB. Higuchi RI, et al. J Med Chem. 2007 May 17;50(10):2486-96. doi: 10.1021/jm061329j. Epub 2007 Apr 17. J Med Chem. 2007. PMID: 17439112

4

Synthesis and biological activity of 5-methylidene 1,2-dihydrochromeno[3,4-f]quinoline derivatives as progesterone receptor modulators.

Zhi L, Tegley CM, Pio B, Edwards JP, Jones TK, Marschke KB, Mais DE, Risek B, Schrader WT. Zhi L, et al. Bioorg Med Chem Lett. 2003 Jun 16;13(12):2071-4. doi: 10.1016/s0960-894x(03)00255-5. Bioorg Med Chem Lett. 2003. PMID: 12781197

5

5-benzylidene-1,2-dihydrochromeno[3,4-f]quinolines as selective progesterone receptor modulators.

Zhi L, Tegley CM, Pio B, Edwards JP, Motamedi M, Jones TK, Marschke KB, Mais DE, Risek B, Schrader WT. Zhi L, et al. J Med Chem. 2003 Sep 11;46(19):4104-12. doi: 10.1021/jm020477g. J Med Chem. 2003. PMID: 12954062

6

Potent, nonsteroidal selective androgen receptor modulators (SARMs) based on 8H-[1,4]oxazino[2,3-f]quinolin-8-ones.

Higuchi RI, Thompson AW, Chen JH, Caferro TR, Cummings ML, Deckhut CP, Adams ME, Tegley CM, Edwards JP, López FJ, Kallel EA, Karanewsky DS, Schrader WT, Marschke KB, Zhi L. Higuchi RI, et al. Among authors: schrader wt. Bioorg Med Chem Lett. 2007 Oct 1;17(19):5442-6. doi: 10.1016/j.bmcl.2007.07.034. Epub 2007 Jul 25. Bioorg Med Chem Lett. 2007. PMID: 17703938 Free PMC article.

7

Development of progesterone receptor antagonists from 1,2-dihydrochromeno[3,4-f]quinoline agonist pharmacophore.

Zhi L, Ringgenberg JD, Edwards JP, Tegley CM, West SJ, Pio B, Motamedi M, Jones TK, Marschke KB, Mais DE, Schrader WT. Zhi L, et al. Bioorg Med Chem Lett. 2003 Jun 16;13(12):2075-8. doi: 10.1016/s0960-894x(03)00256-7. Bioorg Med Chem Lett. 2003. PMID: 12781198

8

Preparation, resolution, and biological evaluation of 5-aryl-1, 2-dihydro-5H-chromeno[3,4-f]quinolines: potent, orally active, nonsteroidal progesterone receptor agonists.

Edwards JP, Zhi L, Pooley CL, Tegley CM, West SJ, Wang MW, Gottardis MM, Pathirana C, Schrader WT, Jones TK. Edwards JP, et al. Among authors: schrader wt. J Med Chem. 1998 Jul 16;41(15):2779-85. doi: 10.1021/jm980190c. J Med Chem. 1998. PMID: 9667968

9

Differential hormone-dependent phosphorylation of progesterone receptor A and B forms revealed by a phosphoserine site-specific monoclonal antibody.

Clemm DL, Sherman L, Boonyaratanakornkit V, Schrader WT, Weigel NL, Edwards DP. Clemm DL, et al. Among authors: schrader wt. Mol Endocrinol. 2000 Jan;14(1):52-65. doi: 10.1210/mend.14.1.0413. Mol Endocrinol. 2000. PMID: 10628747

10

Androgen receptor-mediated apoptosis is regulated by photoactivatable androgen receptor ligands.

Risek B, Bilski P, Rice AB, Schrader WT. Risek B, et al. Mol Endocrinol. 2008 Sep;22(9):2099-115. doi: 10.1210/me.2007-0426. Epub 2008 Jun 18. Mol Endocrinol. 2008. PMID: 18562628 Free PMC article.

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