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The antiviral efficacy of simian immunodeficiency virus-specific CD8+ T cells is unrelated to epitope specificity and is abrogated by viral escape.
Loffredo JT, Burwitz BJ, Rakasz EG, Spencer SP, Stephany JJ, Vela JP, Martin SR, Reed J, Piaskowski SM, Furlott J, Weisgrau KL, Rodrigues DS, Soma T, Napoé G, Friedrich TC, Wilson NA, Kallas EG, Watkins DI. Loffredo JT, et al. J Virol. 2007 Mar;81(6):2624-34. doi: 10.1128/JVI.01912-06. Epub 2006 Dec 27. J Virol. 2007. PMID: 17192314 Free PMC article.
Gag-specific CD8+ T lymphocytes recognize infected cells before AIDS-virus integration and viral protein expression.
Sacha JB, Chung C, Rakasz EG, Spencer SP, Jonas AK, Bean AT, Lee W, Burwitz BJ, Stephany JJ, Loffredo JT, Allison DB, Adnan S, Hoji A, Wilson NA, Friedrich TC, Lifson JD, Yang OO, Watkins DI. Sacha JB, et al. Among authors: loffredo jt. J Immunol. 2007 Mar 1;178(5):2746-54. doi: 10.4049/jimmunol.178.5.2746. J Immunol. 2007. PMID: 17312117 Free PMC article.
Mamu-B*08-positive macaques control simian immunodeficiency virus replication.
Loffredo JT, Maxwell J, Qi Y, Glidden CE, Borchardt GJ, Soma T, Bean AT, Beal DR, Wilson NA, Rehrauer WM, Lifson JD, Carrington M, Watkins DI. Loffredo JT, et al. J Virol. 2007 Aug;81(16):8827-32. doi: 10.1128/JVI.00895-07. Epub 2007 May 30. J Virol. 2007. PMID: 17537848 Free PMC article.
The major histocompatibility complex class II alleles Mamu-DRB1*1003 and -DRB1*0306 are enriched in a cohort of simian immunodeficiency virus-infected rhesus macaque elite controllers.
Giraldo-Vela JP, Rudersdorf R, Chung C, Qi Y, Wallace LT, Bimber B, Borchardt GJ, Fisk DL, Glidden CE, Loffredo JT, Piaskowski SM, Furlott JR, Morales-Martinez JP, Wilson NA, Rehrauer WM, Lifson JD, Carrington M, Watkins DI. Giraldo-Vela JP, et al. Among authors: loffredo jt. J Virol. 2008 Jan;82(2):859-70. doi: 10.1128/JVI.01816-07. Epub 2007 Nov 7. J Virol. 2008. PMID: 17989178 Free PMC article.
CD8+ T cells from SIV elite controller macaques recognize Mamu-B*08-bound epitopes and select for widespread viral variation.
Loffredo JT, Friedrich TC, León EJ, Stephany JJ, Rodrigues DS, Spencer SP, Bean AT, Beal DR, Burwitz BJ, Rudersdorf RA, Wallace LT, Piaskowski SM, May GE, Sidney J, Gostick E, Wilson NA, Price DA, Kallas EG, Piontkivska H, Hughes AL, Sette A, Watkins DI. Loffredo JT, et al. PLoS One. 2007 Nov 14;2(11):e1152. doi: 10.1371/journal.pone.0001152. PLoS One. 2007. PMID: 18000532 Free PMC article.
Patterns of CD8+ immunodominance may influence the ability of Mamu-B*08-positive macaques to naturally control simian immunodeficiency virus SIVmac239 replication.
Loffredo JT, Bean AT, Beal DR, León EJ, May GE, Piaskowski SM, Furlott JR, Reed J, Musani SK, Rakasz EG, Friedrich TC, Wilson NA, Allison DB, Watkins DI. Loffredo JT, et al. J Virol. 2008 Feb;82(4):1723-38. doi: 10.1128/JVI.02084-07. Epub 2007 Dec 5. J Virol. 2008. PMID: 18057253 Free PMC article.
Comprehensive immunological evaluation reveals surprisingly few differences between elite controller and progressor Mamu-B*17-positive simian immunodeficiency virus-infected rhesus macaques.
Maness NJ, Yant LJ, Chung C, Loffredo JT, Friedrich TC, Piaskowski SM, Furlott J, May GE, Soma T, León EJ, Wilson NA, Piontkivska H, Hughes AL, Sidney J, Sette A, Watkins DI. Maness NJ, et al. Among authors: loffredo jt. J Virol. 2008 Jun;82(11):5245-54. doi: 10.1128/JVI.00292-08. Epub 2008 Apr 2. J Virol. 2008. PMID: 18385251 Free PMC article.
29 results