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Gene targeting using a promoterless gene trap vector ("targeted trapping") is an efficient method to mutate a large fraction of genes.
Friedel RH, Plump A, Lu X, Spilker K, Jolicoeur C, Wong K, Venkatesh TR, Yaron A, Hynes M, Chen B, Okada A, McConnell SK, Rayburn H, Tessier-Lavigne M. Friedel RH, et al. Proc Natl Acad Sci U S A. 2005 Sep 13;102(37):13188-93. doi: 10.1073/pnas.0505474102. Epub 2005 Aug 29. Proc Natl Acad Sci U S A. 2005. PMID: 16129827 Free PMC article.
Generating conditional knockout mice.
Friedel RH, Wurst W, Wefers B, Kühn R. Friedel RH, et al. Methods Mol Biol. 2011;693:205-31. doi: 10.1007/978-1-60761-974-1_12. Methods Mol Biol. 2011. PMID: 21080282
Semaphorin-Plexin Signaling Controls Mitotic Spindle Orientation during Epithelial Morphogenesis and Repair.
Xia J, Swiercz JM, Bañón-Rodríguez I, Matković I, Federico G, Sun T, Franz T, Brakebusch CH, Kumanogoh A, Friedel RH, Martín-Belmonte F, Gröne HJ, Offermanns S, Worzfeld T. Xia J, et al. Among authors: friedel rh. Dev Cell. 2015 May 4;33(3):299-313. doi: 10.1016/j.devcel.2015.02.001. Epub 2015 Apr 16. Dev Cell. 2015. PMID: 25892012 Free article.
Plexin-B2 controls the development of cerebellar granule cells.
Friedel RH, Kerjan G, Rayburn H, Schüller U, Sotelo C, Tessier-Lavigne M, Chédotal A. Friedel RH, et al. J Neurosci. 2007 Apr 4;27(14):3921-32. doi: 10.1523/JNEUROSCI.4710-06.2007. J Neurosci. 2007. PMID: 17409257 Free PMC article.
Semaphorin 4C and 4G are ligands of Plexin-B2 required in cerebellar development.
Maier V, Jolicoeur C, Rayburn H, Takegahara N, Kumanogoh A, Kikutani H, Tessier-Lavigne M, Wurst W, Friedel RH. Maier V, et al. Among authors: friedel rh. Mol Cell Neurosci. 2011 Feb;46(2):419-31. doi: 10.1016/j.mcn.2010.11.005. Epub 2010 Nov 29. Mol Cell Neurosci. 2011. PMID: 21122816 Free PMC article.
EUCOMM--the European conditional mouse mutagenesis program.
Friedel RH, Seisenberger C, Kaloff C, Wurst W. Friedel RH, et al. Brief Funct Genomic Proteomic. 2007 Sep;6(3):180-5. doi: 10.1093/bfgp/elm022. Epub 2007 Oct 29. Brief Funct Genomic Proteomic. 2007. PMID: 17967808
The mammalian gene function resource: the International Knockout Mouse Consortium.
Bradley A, Anastassiadis K, Ayadi A, Battey JF, Bell C, Birling MC, Bottomley J, Brown SD, Bürger A, Bult CJ, Bushell W, Collins FS, Desaintes C, Doe B, Economides A, Eppig JT, Finnell RH, Fletcher C, Fray M, Frendewey D, Friedel RH, Grosveld FG, Hansen J, Hérault Y, Hicks G, Hörlein A, Houghton R, Hrabé de Angelis M, Huylebroeck D, Iyer V, de Jong PJ, Kadin JA, Kaloff C, Kennedy K, Koutsourakis M, Lloyd KC, Marschall S, Mason J, McKerlie C, McLeod MP, von Melchner H, Moore M, Mujica AO, Nagy A, Nefedov M, Nutter LM, Pavlovic G, Peterson JL, Pollock J, Ramirez-Solis R, Rancourt DE, Raspa M, Remacle JE, Ringwald M, Rosen B, Rosenthal N, Rossant J, Ruiz Noppinger P, Ryder E, Schick JZ, Schnütgen F, Schofield P, Seisenberger C, Selloum M, Simpson EM, Skarnes WC, Smedley D, Stanford WL, Stewart AF, Stone K, Swan K, Tadepally H, Teboul L, Tocchini-Valentini GP, Valenzuela D, West AP, Yamamura K, Yoshinaga Y, Wurst W. Bradley A, et al. Among authors: friedel rh. Mamm Genome. 2012 Oct;23(9-10):580-6. doi: 10.1007/s00335-012-9422-2. Epub 2012 Sep 12. Mamm Genome. 2012. PMID: 22968824 Free PMC article.
66 results