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The LXR agonist TO901317 selectively lowers hippocampal Abeta42 and improves memory in the Tg2576 mouse model of Alzheimer's disease.
Riddell DR, Zhou H, Comery TA, Kouranova E, Lo CF, Warwick HK, Ring RH, Kirksey Y, Aschmies S, Xu J, Kubek K, Hirst WD, Gonzales C, Chen Y, Murphy E, Leonard S, Vasylyev D, Oganesian A, Martone RL, Pangalos MN, Reinhart PH, Jacobsen JS. Riddell DR, et al. Among authors: vasylyev d. Mol Cell Neurosci. 2007 Apr;34(4):621-8. doi: 10.1016/j.mcn.2007.01.011. Epub 2007 Jan 25. Mol Cell Neurosci. 2007. PMID: 17336088
Amiloride is neuroprotective in an MPTP model of Parkinson's disease.
Arias RL, Sung ML, Vasylyev D, Zhang MY, Albinson K, Kubek K, Kagan N, Beyer C, Lin Q, Dwyer JM, Zaleska MM, Bowlby MR, Dunlop J, Monaghan M. Arias RL, et al. Among authors: vasylyev d. Neurobiol Dis. 2008 Sep;31(3):334-41. doi: 10.1016/j.nbd.2008.05.008. Epub 2008 Jul 7. Neurobiol Dis. 2008. PMID: 18606547
Nav1.7 as a chondrocyte regulator and therapeutic target for osteoarthritis.
Fu W, Vasylyev D, Bi Y, Zhang M, Sun G, Khleborodova A, Huang G, Zhao L, Zhou R, Li Y, Liu S, Cai X, He W, Cui M, Zhao X, Hettinghouse A, Good J, Kim E, Strauss E, Leucht P, Schwarzkopf R, Guo EX, Samuels J, Hu W, Attur M, Waxman SG, Liu CJ. Fu W, et al. Among authors: vasylyev d. Nature. 2024 Jan;625(7995):557-565. doi: 10.1038/s41586-023-06888-7. Epub 2024 Jan 3. Nature. 2024. PMID: 38172636 Free PMC article.
16 results