Lockwood PA - Search Results

1

Lalonde RL, Kowalski KG, Hutmacher MM, Ewy W, Nichols DJ, Milligan PA, Corrigan BW, Lockwood PA, Marshall SA, Benincosa LJ, Tensfeldt TG, Parivar K, Amantea M, Glue P, Koide H, Miller R. Lalonde RL, et al. Among authors: lockwood pa. Clin Pharmacol Ther. 2007 Jul;82(1):21-32. doi: 10.1038/sj.clpt.6100235. Epub 2007 May 23. Clin Pharmacol Ther. 2007. PMID: 17522597 Review.

2

The use of clinical trial simulation to support dose selection: application to development of a new treatment for chronic neuropathic pain.

Lockwood PA, Cook JA, Ewy WE, Mandema JW. Lockwood PA, et al. Pharm Res. 2003 Nov;20(11):1752-9. doi: 10.1023/b:pham.0000003371.32474.ee. Pharm Res. 2003. PMID: 14661918

3

How modeling and simulation have enhanced decision making in new drug development.

Miller R, Ewy W, Corrigan BW, Ouellet D, Hermann D, Kowalski KG, Lockwood P, Koup JR, Donevan S, El-Kattan A, Li CS, Werth JL, Feltner DE, Lalonde RL. Miller R, et al. J Pharmacokinet Pharmacodyn. 2005 Apr;32(2):185-97. doi: 10.1007/s10928-005-0074-7. Epub 2005 Nov 7. J Pharmacokinet Pharmacodyn. 2005. PMID: 16283534 Review.

4

Application of clinical trial simulation to compare proof-of-concept study designs for drugs with a slow onset of effect; an example in Alzheimer's disease.

Lockwood P, Ewy W, Hermann D, Holford N. Lockwood P, et al. Pharm Res. 2006 Sep;23(9):2050-9. doi: 10.1007/s11095-006-9048-8. Epub 2006 Aug 12. Pharm Res. 2006. PMID: 16906456 Clinical Trial.

5

Quantitative prediction of renal transporter-mediated clinical drug-drug interactions.

Feng B, Hurst S, Lu Y, Varma MV, Rotter CJ, El-Kattan A, Lockwood P, Corrigan B. Feng B, et al. Mol Pharm. 2013 Nov 4;10(11):4207-15. doi: 10.1021/mp400295c. Epub 2013 Oct 10. Mol Pharm. 2013. PMID: 24066726

6

The Bioequivalence of Tafamidis 61-mg Free Acid Capsules and Tafamidis Meglumine 4 × 20-mg Capsules in Healthy Volunteers.

Lockwood PA, Le VH, O'Gorman MT, Patterson TA, Sultan MB, Tankisheva E, Wang Q, Riley S. Lockwood PA, et al. Clin Pharmacol Drug Dev. 2020 Oct;9(7):849-854. doi: 10.1002/cpdd.789. Epub 2020 Mar 20. Clin Pharmacol Drug Dev. 2020. PMID: 32196976 Free PMC article. Clinical Trial.

7

A Phase 2 clinical trial of PF-05212377 (SAM-760) in subjects with mild to moderate Alzheimer's disease with existing neuropsychiatric symptoms on a stable daily dose of donepezil.

Fullerton T, Binneman B, David W, Delnomdedieu M, Kupiec J, Lockwood P, Mancuso J, Miceli J, Bell J. Fullerton T, et al. Alzheimers Res Ther. 2018 Apr 5;10(1):38. doi: 10.1186/s13195-018-0368-9. Alzheimers Res Ther. 2018. PMID: 29622037 Free PMC article. Clinical Trial.

8

Metabolism of a 5HT₆ Antagonist, 2-Methyl-1-(Phenylsulfonyl)-4-(Piperazin-1-yl)-1H-Benzo[d]imidazole (SAM-760): Impact of Sulfonamide Metabolism on Diminution of a Ketoconazole-Mediated Clinical Drug-Drug Interaction.

Sawant-Basak A, Obach RS, Doran A, Lockwood P, Schildknegt K, Gao H, Mancuso J, Tse S, Comery TA. Sawant-Basak A, et al. Drug Metab Dispos. 2018 Jul;46(7):934-942. doi: 10.1124/dmd.118.080457. Epub 2018 Apr 25. Drug Metab Dispos. 2018. PMID: 29695615

9

The Pharmacokinetics of Pregabalin in Breast Milk, Plasma, and Urine of Healthy Postpartum Women.

Lockwood PA, Pauer L, Scavone JM, Allard M, Mendes da Costa L, Alebic-Kolbah T, Plotka A, Alvey CW, Chew ML. Lockwood PA, et al. J Hum Lact. 2016 Aug 1;32(3):NP1-NP8. doi: 10.1177/0890334415626148. Epub 2016 Mar 9. J Hum Lact. 2016. PMID: 26961752

10

The Economic Impact of New Therapeutic Interventions on Neuropsychiatric Inventory (NPI) Symptom Scores in Patients with Alzheimer Disease.

Tafazzoli A, Kansal A, Lockwood P, Petrie C, Barsdorf A. Tafazzoli A, et al. Dement Geriatr Cogn Dis Extra. 2018 Apr 26;8(1):158-173. doi: 10.1159/000488140. eCollection 2018 Jan-Apr. Dement Geriatr Cogn Dis Extra. 2018. PMID: 29805382 Free PMC article.

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