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Thiophene-anthranilamides as highly potent and orally available factor Xa inhibitors.
J Med Chem. 2007 Jun 28;50(13):2967-80. doi: 10.1021/jm070125f. Epub 2007 May 31.
J Med Chem. 2007.
PMID: 17536795
Crystal structures of two potent nonamidine inhibitors bound to factor Xa.
Adler M, Kochanny MJ, Ye B, Rumennik G, Light DR, Biancalana S, Whitlow M.
Adler M, et al. Among authors: rumennik g.
Biochemistry. 2002 Dec 31;41(52):15514-23. doi: 10.1021/bi0264061.
Biochemistry. 2002.
PMID: 12501180
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Discovery and characterization of a potent and selective non-amidine inhibitor of human factor Xa.
Liang AM, Light DR, Kochanny M, Rumennik G, Trinh L, Lentz D, Post J, Morser J, Snider M.
Liang AM, et al. Among authors: rumennik g.
Biochem Pharmacol. 2003 May 1;65(9):1407-18. doi: 10.1016/s0006-2952(03)00084-4.
Biochem Pharmacol. 2003.
PMID: 12732352
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Preparation, characterization, and the crystal structure of the inhibitor ZK-807834 (CI-1031) complexed with factor Xa.
Adler M, Davey DD, Phillips GB, Kim SH, Jancarik J, Rumennik G, Light DR, Whitlow M.
Adler M, et al. Among authors: rumennik g.
Biochemistry. 2000 Oct 17;39(41):12534-42. doi: 10.1021/bi001477q.
Biochemistry. 2000.
PMID: 11027132
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Effects of ZK-807834, a novel inhibitor of factor Xa, on arterial and venous thrombosis in rabbits.
Abendschein DR, Baum PK, Martin DJ, Vergona R, Post J, Rumennik G, Sullivan ME, Eisenberg PR, Light DR.
Abendschein DR, et al. Among authors: rumennik g.
J Cardiovasc Pharmacol. 2000 May;35(5):796-805. doi: 10.1097/00005344-200005000-00018.
J Cardiovasc Pharmacol. 2000.
PMID: 10813384
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The interaction of thrombomodulin with Ca2+.
Light DR, Glaser CB, Betts M, Blasko E, Campbell E, Clarke JH, McCaman M, McLean K, Nagashima M, Parkinson JF, Rumennik G, Young T, Morser J.
Light DR, et al. Among authors: rumennik g.
Eur J Biochem. 1999 Jun;262(2):522-33. doi: 10.1046/j.1432-1327.1999.00398.x.
Eur J Biochem. 1999.
PMID: 10336638
Free article.
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Structural basis for the anticoagulant activity of the thrombin-thrombomodulin complex.
Fuentes-Prior P, Iwanaga Y, Huber R, Pagila R, Rumennik G, Seto M, Morser J, Light DR, Bode W.
Fuentes-Prior P, et al. Among authors: rumennik g.
Nature. 2000 Mar 30;404(6777):518-25. doi: 10.1038/35006683.
Nature. 2000.
PMID: 10761923
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