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Thiophene-anthranilamides as highly potent and orally available factor Xa inhibitors.
Ye B, Arnaiz DO, Chou YL, Griedel BD, Karanjawala R, Lee W, Morrissey MM, Sacchi KL, Sakata ST, Shaw KJ, Wu SC, Zhao Z, Adler M, Cheeseman S, Dole WP, Ewing J, Fitch R, Lentz D, Liang A, Light D, Morser J, Post J, Rumennik G, Subramanyam B, Sullivan ME, Vergona R, Walters J, Wang YX, White KA, Whitlow M, Kochanny MJ. Ye B, et al. Among authors: shaw kj. J Med Chem. 2007 Jun 28;50(13):2967-80. doi: 10.1021/jm070125f. Epub 2007 May 31. J Med Chem. 2007. PMID: 17536795
Design, synthesis, and biological activity of novel factor Xa inhibitors: 4-aryloxy substituents of 2,6-diphenoxypyridines.
Ng HP, Buckman BO, Eagen KA, Guilford WJ, Kochanny MJ, Mohan R, Shaw KJ, Wu SC, Lentz D, Liang A, Trinh L, Ho E, Smith D, Subramanyam B, Vergona R, Walters J, White KA, Sullivan ME, Morrissey MM, Phillips GB. Ng HP, et al. Among authors: shaw kj. Bioorg Med Chem. 2002 Mar;10(3):657-66. doi: 10.1016/s0968-0896(01)00338-8. Bioorg Med Chem. 2002. PMID: 11814853
Design and synthesis of aminophenol-based factor Xa inhibitors.
Wu S, Guilford WJ, Chou YL, Griedel BD, Liang A, Sakata S, Shaw KJ, Trinh L, Xu W, Zhao Z, Morrissey MM. Wu S, et al. Among authors: shaw kj. Bioorg Med Chem Lett. 2002 May 6;12(9):1307-10. doi: 10.1016/s0960-894x(02)00142-7. Bioorg Med Chem Lett. 2002. PMID: 11965377
Substituted thiophene-anthranilamides as potent inhibitors of human factor Xa.
Kochanny MJ, Adler M, Ewing J, Griedel BD, Ho E, Karanjawala R, Lee W, Lentz D, Liang AM, Morrissey MM, Phillips GB, Post J, Sacchi KL, Sakata ST, Subramanyam B, Vergona R, Walters J, White KA, Whitlow M, Ye B, Zhao Z, Shaw KJ. Kochanny MJ, et al. Among authors: shaw kj. Bioorg Med Chem. 2007 Mar 1;15(5):2127-46. doi: 10.1016/j.bmc.2006.12.019. Epub 2006 Dec 13. Bioorg Med Chem. 2007. PMID: 17227710
Discovery of N-[2-[5-[Amino(imino)methyl]-2-hydroxyphenoxy]-3, 5-difluoro-6-[3-(4, 5-dihydro-1-methyl-1H-imidazol-2-yl)phenoxy]pyridin-4-yl]-N-methylgl y cine (ZK-807834): a potent, selective, and orally active inhibitor of the blood coagulation enzyme factor Xa.
Phillips GB, Buckman BO, Davey DD, Eagen KA, Guilford WJ, Hinchman J, Ho E, Koovakkat S, Liang A, Light DR, Mohan R, Ng HP, Post JM, Shaw KJ, Smith D, Subramanyam B, Sullivan ME, Trinh L, Vergona R, Walters J, White K, Whitlow M, Wu S, Xu W, Morrissey MM. Phillips GB, et al. Among authors: shaw kj. J Med Chem. 1998 Sep 10;41(19):3557-62. doi: 10.1021/jm980280h. J Med Chem. 1998. PMID: 9733480 No abstract available.
170 results