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MLL-rearranged B lymphoblastic leukemias selectively express the immunoregulatory carbohydrate-binding protein galectin-1.
Juszczynski P, Rodig SJ, Ouyang J, O'Donnell E, Takeyama K, Mlynarski W, Mycko K, Szczepanski T, Gaworczyk A, Krivtsov A, Faber J, Sinha AU, Rabinovich GA, Armstrong SA, Kutok JL, Shipp MA. Juszczynski P, et al. Among authors: rabinovich ga. Clin Cancer Res. 2010 Apr 1;16(7):2122-30. doi: 10.1158/1078-0432.CCR-09-2765. Epub 2010 Mar 23. Clin Cancer Res. 2010. PMID: 20332322 Free PMC article.
Disrupting galectin-1 interactions with N-glycans suppresses hypoxia-driven angiogenesis and tumorigenesis in Kaposi's sarcoma.
Croci DO, Salatino M, Rubinstein N, Cerliani JP, Cavallin LE, Leung HJ, Ouyang J, Ilarregui JM, Toscano MA, Domaica CI, Croci MC, Shipp MA, Mesri EA, Albini A, Rabinovich GA. Croci DO, et al. Among authors: rabinovich ga. J Exp Med. 2012 Oct 22;209(11):1985-2000. doi: 10.1084/jem.20111665. Epub 2012 Oct 1. J Exp Med. 2012. PMID: 23027923 Free PMC article.
A unique galectin signature in human prostate cancer progression suggests galectin-1 as a key target for treatment of advanced disease.
Laderach DJ, Gentilini LD, Giribaldi L, Delgado VC, Nugnes L, Croci DO, Al Nakouzi N, Sacca P, Casas G, Mazza O, Shipp MA, Vazquez E, Chauchereau A, Kutok JL, Rodig SJ, Elola MT, Compagno D, Rabinovich GA. Laderach DJ, et al. Among authors: rabinovich ga. Cancer Res. 2013 Jan 1;73(1):86-96. doi: 10.1158/0008-5472.CAN-12-1260. Epub 2012 Oct 29. Cancer Res. 2013. PMID: 23108139
Glycosylation-dependent lectin-receptor interactions preserve angiogenesis in anti-VEGF refractory tumors.
Croci DO, Cerliani JP, Dalotto-Moreno T, Méndez-Huergo SP, Mascanfroni ID, Dergan-Dylon S, Toscano MA, Caramelo JJ, García-Vallejo JJ, Ouyang J, Mesri EA, Junttila MR, Bais C, Shipp MA, Salatino M, Rabinovich GA. Croci DO, et al. Among authors: rabinovich ga. Cell. 2014 Feb 13;156(4):744-58. doi: 10.1016/j.cell.2014.01.043. Cell. 2014. PMID: 24529377 Free article.
Suppression of age-related salivary gland autoimmunity by glycosylation-dependent galectin-1-driven immune inhibitory circuits.
Martínez Allo VC, Hauk V, Sarbia N, Pinto NA, Croci DO, Dalotto-Moreno T, Morales RM, Gatto SG, Manselle Cocco MN, Stupirski JC, Deladoey Á, Maronna E, Marcaida P, Durigan V, Secco A, Mamani M, Dos Santos A, Catalán Pellet A, Pérez Leiros C, Rabinovich GA, Toscano MA. Martínez Allo VC, et al. Among authors: rabinovich ga. Proc Natl Acad Sci U S A. 2020 Mar 24;117(12):6630-6639. doi: 10.1073/pnas.1922778117. Epub 2020 Mar 11. Proc Natl Acad Sci U S A. 2020. PMID: 32161138 Free PMC article.
325 results