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Progressive CD4+ central memory T cell decline results in CD4+ effector memory insufficiency and overt disease in chronic SIV infection.
Okoye A, Meier-Schellersheim M, Brenchley JM, Hagen SI, Walker JM, Rohankhedkar M, Lum R, Edgar JB, Planer SL, Legasse A, Sylwester AW, Piatak M Jr, Lifson JD, Maino VC, Sodora DL, Douek DC, Axthelm MK, Grossman Z, Picker LJ. Okoye A, et al. Among authors: grossman z. J Exp Med. 2007 Sep 3;204(9):2171-85. doi: 10.1084/jem.20070567. Epub 2007 Aug 27. J Exp Med. 2007. PMID: 17724130 Free PMC article.
High production rates sustain in vivo levels of PD-1high simian immunodeficiency virus-specific CD8 T cells in the face of rapid clearance.
Petrovas C, Yamamoto T, Price DA, Rao SS, Klatt NR, Brenchley JM, Douek DC, Gostick E, Angermann BR, Grossman Z, Macallan DC, Meier-Schellersheim M, Koup RA. Petrovas C, et al. Among authors: grossman z. J Virol. 2013 Sep;87(17):9836-44. doi: 10.1128/JVI.01001-13. Epub 2013 Jul 3. J Virol. 2013. PMID: 23824823 Free PMC article.
HIV preferentially infects HIV-specific CD4+ T cells.
Douek DC, Brenchley JM, Betts MR, Ambrozak DR, Hill BJ, Okamoto Y, Casazza JP, Kuruppu J, Kunstman K, Wolinsky S, Grossman Z, Dybul M, Oxenius A, Price DA, Connors M, Koup RA. Douek DC, et al. Among authors: grossman z. Nature. 2002 May 2;417(6884):95-8. doi: 10.1038/417095a. Nature. 2002. PMID: 11986671
Feedback regulation of proliferation vs. differentiation rates explains the dependence of CD4 T-cell expansion on precursor number.
Bocharov G, Quiel J, Luzyanina T, Alon H, Chiglintsev E, Chereshnev V, Meier-Schellersheim M, Paul WE, Grossman Z. Bocharov G, et al. Among authors: grossman z. Proc Natl Acad Sci U S A. 2011 Feb 22;108(8):3318-23. doi: 10.1073/pnas.1019706108. Epub 2011 Feb 3. Proc Natl Acad Sci U S A. 2011. PMID: 21292990 Free PMC article.
298 results