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Anti-inflammatory activity of human IgG4 antibodies by dynamic Fab arm exchange.
Science. 2007 Sep 14;317(5844):1554-7. doi: 10.1126/science.1144603.
Science. 2007.
PMID: 17872445
Hybrid IgG4/IgG4 Fc antibodies form upon 'Fab-arm' exchange as demonstrated by SDS-PAGE or size-exclusion chromatography.
Rispens T, den Bleker TH, Aalberse RC.
Rispens T, et al. Among authors: den bleker th.
Mol Immunol. 2010 Apr;47(7-8):1592-4. doi: 10.1016/j.molimm.2010.02.021. Epub 2010 Mar 17.
Mol Immunol. 2010.
PMID: 20299101
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Species-specific determinants in the IgG CH3 domain enable Fab-arm exchange by affecting the noncovalent CH3-CH3 interaction strength.
Labrijn AF, Rispens T, Meesters J, Rose RJ, den Bleker TH, Loverix S, van den Bremer ET, Neijssen J, Vink T, Lasters I, Aalberse RC, Heck AJ, van de Winkel JG, Schuurman J, Parren PW.
Labrijn AF, et al. Among authors: den bleker th.
J Immunol. 2011 Sep 15;187(6):3238-46. doi: 10.4049/jimmunol.1003336. Epub 2011 Aug 12.
J Immunol. 2011.
PMID: 21841137
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Fc-Fc interactions of human IgG4 require dissociation of heavy chains and are formed predominantly by the intra-chain hinge isomer.
Rispens T, Meesters J, den Bleker TH, Ooijevaar-De Heer P, Schuurman J, Parren PW, Labrijn A, Aalberse RC.
Rispens T, et al. Among authors: den bleker th.
Mol Immunol. 2013 Jan;53(1-2):35-42. doi: 10.1016/j.molimm.2012.06.012. Epub 2012 Jul 10.
Mol Immunol. 2013.
PMID: 22784992
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Traces of pFc' in IVIG interact with human IgG Fc domains and counteract aggregation.
Rispens T, Himly M, Ooievaar-De Heer P, den Bleker TH, Aalberse RC.
Rispens T, et al. Among authors: den bleker th.
Eur J Pharm Sci. 2010 Apr 16;40(1):62-8. doi: 10.1016/j.ejps.2010.03.001. Epub 2010 Mar 6.
Eur J Pharm Sci. 2010.
PMID: 20211252
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Crystal structure of the human IgG4 C(H)3 dimer reveals the role of Arg409 in the mechanism of Fab-arm exchange.
Davies AM, Rispens T, den Bleker TH, McDonnell JM, Gould HJ, Aalberse RC, Sutton BJ.
Davies AM, et al. Among authors: den bleker th.
Mol Immunol. 2013 May;54(1):1-7. doi: 10.1016/j.molimm.2012.10.029. Epub 2012 Nov 17.
Mol Immunol. 2013.
PMID: 23164605
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