Scotney P - Search Results

1

Prophylactic but not therapeutic activity of a monoclonal antibody that neutralizes the binding of VEGF-B to VEGFR-1 in a murine collagen-induced arthritis model.

Mould AW, Scotney P, Greco SA, Hayward NK, Nash A, Kay GF. Mould AW, et al. Among authors: scotney p. Rheumatology (Oxford). 2008 Mar;47(3):263-6. doi: 10.1093/rheumatology/kem369. Epub 2008 Jan 19. Rheumatology (Oxford). 2008. PMID: 18204088

2

Human vascular endothelial growth factor B: characterization of recombinant isoforms and generation of neutralizing monoclonal antibodies.

Scotney PD, MacKenzie A, Maccarone P, Fabri LJ, Scrofani SD, Gooley PR, Nash AD. Scotney PD, et al. Clin Exp Pharmacol Physiol. 2002 Nov;29(11):1024-9. doi: 10.1046/j.1440-1681.2002.03769.x. Clin Exp Pharmacol Physiol. 2002. PMID: 12366396

3

Transgenic overexpression of vascular endothelial growth factor-B isoforms by endothelial cells potentiates postnatal vessel growth in vivo and in vitro.

Mould AW, Greco SA, Cahill MM, Tonks ID, Bellomo D, Patterson C, Zournazi A, Nash A, Scotney P, Hayward NK, Kay GF. Mould AW, et al. Among authors: scotney p. Circ Res. 2005 Sep 16;97(6):e60-70. doi: 10.1161/01.RES.0000182631.33638.77. Epub 2005 Aug 18. Circ Res. 2005. PMID: 16109918

4

The biology of vascular endothelial growth factor-B (VEGF-B).

Nash AD, Baca M, Wright C, Scotney PD. Nash AD, et al. Pulm Pharmacol Ther. 2006;19(1):61-9. doi: 10.1016/j.pupt.2005.02.007. Epub 2005 Apr 25. Pulm Pharmacol Ther. 2006. PMID: 16286239 Review.

5

Crystal structure of human vascular endothelial growth factor-B: identification of amino acids important for receptor binding.

Iyer S, Scotney PD, Nash AD, Ravi Acharya K. Iyer S, et al. J Mol Biol. 2006 May 26;359(1):76-85. doi: 10.1016/j.jmb.2006.03.002. Epub 2006 Apr 17. J Mol Biol. 2006. PMID: 16616187

6

VEGF-B inhibits apoptosis via VEGFR-1-mediated suppression of the expression of BH3-only protein genes in mice and rats.

Li Y, Zhang F, Nagai N, Tang Z, Zhang S, Scotney P, Lennartsson J, Zhu C, Qu Y, Fang C, Hua J, Matsuo O, Fong GH, Ding H, Cao Y, Becker KG, Nash A, Heldin CH, Li X. Li Y, et al. Among authors: scotney p. J Clin Invest. 2008 Mar;118(3):913-23. doi: 10.1172/JCI33673. J Clin Invest. 2008. PMID: 18259607 Free PMC article.

7

Crystal structure of vascular endothelial growth factor-B in complex with a neutralising antibody Fab fragment.

Leonard P, Scotney PD, Jabeen T, Iyer S, Fabri LJ, Nash AD, Acharya KR. Leonard P, et al. Among authors: scotney pd. J Mol Biol. 2008 Dec 31;384(5):1203-17. doi: 10.1016/j.jmb.2008.09.076. Epub 2008 Oct 9. J Mol Biol. 2008. PMID: 18930733

8

VEGF-B is dispensable for blood vessel growth but critical for their survival, and VEGF-B targeting inhibits pathological angiogenesis.

Zhang F, Tang Z, Hou X, Lennartsson J, Li Y, Koch AW, Scotney P, Lee C, Arjunan P, Dong L, Kumar A, Rissanen TT, Wang B, Nagai N, Fons P, Fariss R, Zhang Y, Wawrousek E, Tansey G, Raber J, Fong GH, Ding H, Greenberg DA, Becker KG, Herbert JM, Nash A, Yla-Herttuala S, Cao Y, Watts RJ, Li X. Zhang F, et al. Among authors: scotney p. Proc Natl Acad Sci U S A. 2009 Apr 14;106(15):6152-7. doi: 10.1073/pnas.0813061106. Epub 2009 Apr 6. Proc Natl Acad Sci U S A. 2009. PMID: 19369214 Free PMC article.

9

Targeting VEGF-B as a novel treatment for insulin resistance and type 2 diabetes.

Hagberg CE, Mehlem A, Falkevall A, Muhl L, Fam BC, Ortsäter H, Scotney P, Nyqvist D, Samén E, Lu L, Stone-Elander S, Proietto J, Andrikopoulos S, Sjöholm A, Nash A, Eriksson U. Hagberg CE, et al. Among authors: scotney p. Nature. 2012 Oct 18;490(7420):426-30. doi: 10.1038/nature11464. Epub 2012 Sep 26. Nature. 2012. PMID: 23023133

10

Dual mechanism of interleukin-3 receptor blockade by an anti-cancer antibody.

Broughton SE, Hercus TR, Hardy MP, McClure BJ, Nero TL, Dottore M, Huynh H, Braley H, Barry EF, Kan WL, Dhagat U, Scotney P, Hartman D, Busfield SJ, Owczarek CM, Nash AD, Wilson NJ, Parker MW, Lopez AF. Broughton SE, et al. Among authors: scotney p. Cell Rep. 2014 Jul 24;8(2):410-9. doi: 10.1016/j.celrep.2014.06.038. Epub 2014 Jul 17. Cell Rep. 2014. PMID: 25043189 Free article.

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