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A variant of the HTRA1 gene increases susceptibility to age-related macular degeneration.
Yang Z, Camp NJ, Sun H, Tong Z, Gibbs D, Cameron DJ, Chen H, Zhao Y, Pearson E, Li X, Chien J, Dewan A, Harmon J, Bernstein PS, Shridhar V, Zabriskie NA, Hoh J, Howes K, Zhang K. Yang Z, et al. Among authors: chen h. Science. 2006 Nov 10;314(5801):992-3. doi: 10.1126/science.1133811. Epub 2006 Oct 19. Science. 2006. PMID: 17053109
10q26 is associated with increased risk of age-related macular degeneration in the Utah population.
Cameron DJ, Yang Z, Tong Z, Zhao Y, Praggastis A, Brinton E, Harmon J, Chen Y, Pearson E, Bernstein PS, Brinton G, Li X, Jorgensen A, Schneider S, Gibbs D, Chen H, Wang C, Howes K, Camp NJ, Zhang K. Cameron DJ, et al. Among authors: chen h, chen y. Adv Exp Med Biol. 2008;613:253-8. doi: 10.1007/978-0-387-74904-4_29. Adv Exp Med Biol. 2008. PMID: 18188952 No abstract available.
Promoter polymorphism of the erythropoietin gene in severe diabetic eye and kidney complications.
Tong Z, Yang Z, Patel S, Chen H, Gibbs D, Yang X, Hau VS, Kaminoh Y, Harmon J, Pearson E, Buehler J, Chen Y, Yu B, Tinkham NH, Zabriskie NA, Zeng J, Luo L, Sun JK, Prakash M, Hamam RN, Tonna S, Constantine R, Ronquillo CC, Sadda S, Avery RL, Brand JM, London N, Anduze AL, King GL, Bernstein PS, Watkins S; Genetics of Diabetes and Diabetic Complication Study Group; Jorde LB, Li DY, Aiello LP, Pollak MR, Zhang K. Tong Z, et al. Among authors: chen h, chen y. Proc Natl Acad Sci U S A. 2008 May 13;105(19):6998-7003. doi: 10.1073/pnas.0800454105. Epub 2008 May 5. Proc Natl Acad Sci U S A. 2008. PMID: 18458324 Free PMC article.
Genetic susceptibility of diabetic retinopathy.
Patel S, Chen H, Tinkham NH, Zhang K. Patel S, et al. Among authors: chen h. Curr Diab Rep. 2008 Aug;8(4):257-62. doi: 10.1007/s11892-008-0046-6. Curr Diab Rep. 2008. PMID: 18631436 Review.
Mutant prominin 1 found in patients with macular degeneration disrupts photoreceptor disk morphogenesis in mice.
Yang Z, Chen Y, Lillo C, Chien J, Yu Z, Michaelides M, Klein M, Howes KA, Li Y, Kaminoh Y, Chen H, Zhao C, Chen Y, Al-Sheikh YT, Karan G, Corbeil D, Escher P, Kamaya S, Li C, Johnson S, Frederick JM, Zhao Y, Wang C, Cameron DJ, Huttner WB, Schorderet DF, Munier FL, Moore AT, Birch DG, Baehr W, Hunt DM, Williams DS, Zhang K. Yang Z, et al. Among authors: chen h, chen y. J Clin Invest. 2008 Aug;118(8):2908-16. doi: 10.1172/JCI35891. J Clin Invest. 2008. PMID: 18654668 Free PMC article.
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