Bridger G - Search Results

1

Suppression of dualtropic human immunodeficiency virus type 1 by the CXCR4 antagonist AMD3100 is associated with efficiency of CXCR4 use and baseline virus composition.

Fransen S, Bridger G, Whitcomb JM, Toma J, Stawiski E, Parkin N, Petropoulos CJ, Huang W. Fransen S, et al. Among authors: bridger g. Antimicrob Agents Chemother. 2008 Jul;52(7):2608-15. doi: 10.1128/AAC.01226-07. Epub 2008 Apr 28. Antimicrob Agents Chemother. 2008. PMID: 18443125 Free PMC article. Clinical Trial.

2

The CXCR4 antagonist AMD3100 efficiently inhibits cell-surface-expressed human immunodeficiency virus type 1 envelope-induced apoptosis.

Blanco J, Barretina J, Henson G, Bridger G, De Clercq E, Clotet B, Esté JA. Blanco J, et al. Among authors: bridger g. Antimicrob Agents Chemother. 2000 Jan;44(1):51-6. doi: 10.1128/AAC.44.1.51-56.2000. Antimicrob Agents Chemother. 2000. PMID: 10602722 Free PMC article.

3

Pharmacokinetics and safety of AMD-3100, a novel antagonist of the CXCR-4 chemokine receptor, in human volunteers.

Hendrix CW, Flexner C, MacFarland RT, Giandomenico C, Fuchs EJ, Redpath E, Bridger G, Henson GW. Hendrix CW, et al. Among authors: bridger g. Antimicrob Agents Chemother. 2000 Jun;44(6):1667-73. doi: 10.1128/AAC.44.6.1667-1673.2000. Antimicrob Agents Chemother. 2000. PMID: 10817726 Free PMC article. Clinical Trial.

4

Shift of clinical human immunodeficiency virus type 1 isolates from X4 to R5 and prevention of emergence of the syncytium-inducing phenotype by blockade of CXCR4.

Esté JA, Cabrera C, Blanco J, Gutierrez A, Bridger G, Henson G, Clotet B, Schols D, De Clercq E. Esté JA, et al. Among authors: bridger g. J Virol. 1999 Jul;73(7):5577-85. doi: 10.1128/JVI.73.7.5577-5585.1999. J Virol. 1999. PMID: 10364306 Free PMC article.

5

Inhibition of human immunodeficiency virus replication by a dual CCR5/CXCR4 antagonist.

Princen K, Hatse S, Vermeire K, Aquaro S, De Clercq E, Gerlach LO, Rosenkilde M, Schwartz TW, Skerlj R, Bridger G, Schols D. Princen K, et al. Among authors: bridger g. J Virol. 2004 Dec;78(23):12996-3006. doi: 10.1128/JVI.78.23.12996-13006.2004. J Virol. 2004. PMID: 15542651 Free PMC article.

6

The antiviral activity of the CXCR4 antagonist AMD3100 is independent of the cytokine-induced CXCR4/HIV coreceptor expression level.

Princen K, Hatse S, Vermeire K, Bridger GJ, Skerlj RT, De Clercq E, Schols D. Princen K, et al. AIDS Res Hum Retroviruses. 2003 Dec;19(12):1135-9. doi: 10.1089/088922203771881239. AIDS Res Hum Retroviruses. 2003. PMID: 14709250

7

Mutation of Asp(171) and Asp(262) of the chemokine receptor CXCR4 impairs its coreceptor function for human immunodeficiency virus-1 entry and abrogates the antagonistic activity of AMD3100.

Hatse S, Princen K, Gerlach LO, Bridger G, Henson G, De Clercq E, Schwartz TW, Schols D. Hatse S, et al. Among authors: bridger g. Mol Pharmacol. 2001 Jul;60(1):164-73. doi: 10.1124/mol.60.1.164. Mol Pharmacol. 2001. PMID: 11408611

8

Mutations at the CXCR4 interaction sites for AMD3100 influence anti-CXCR4 antibody binding and HIV-1 entry.

Hatse S, Princen K, Vermeire K, Gerlach LO, Rosenkilde MM, Schwartz TW, Bridger G, De Clercq E, Schols D. Hatse S, et al. Among authors: bridger g. FEBS Lett. 2003 Jul 10;546(2-3):300-6. doi: 10.1016/s0014-5793(03)00609-4. FEBS Lett. 2003. PMID: 12832058 Free article.

9

Safety, pharmacokinetics, and antiviral activity of AMD3100, a selective CXCR4 receptor inhibitor, in HIV-1 infection.

Hendrix CW, Collier AC, Lederman MM, Schols D, Pollard RB, Brown S, Jackson JB, Coombs RW, Glesby MJ, Flexner CW, Bridger GJ, Badel K, MacFarland RT, Henson GW, Calandra G; AMD3100 HIV Study Group. Hendrix CW, et al. Among authors: bridger gj. J Acquir Immune Defic Syndr. 2004 Oct 1;37(2):1253-62. doi: 10.1097/01.qai.0000137371.80695.ef. J Acquir Immune Defic Syndr. 2004. PMID: 15385732 Clinical Trial.

10

Structural analogues of AMD3100 mobilise haematopoietic progenitor cells from bone marrow in vivo according to their ability to inhibit CXCL12 binding to CXCR4 in vitro.

Martin C, Bridger GJ, Rankin SM. Martin C, et al. Br J Haematol. 2006 Aug;134(3):326-9. doi: 10.1111/j.1365-2141.2006.06181.x. Epub 2006 Jun 20. Br J Haematol. 2006. PMID: 16787495 Free article.

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