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First-in-human experience of an antidote-controlled anticoagulant using RNA aptamer technology: a phase 1a pharmacodynamic evaluation of a drug-antidote pair for the controlled regulation of factor IXa activity.
Dyke CK, Steinhubl SR, Kleiman NS, Cannon RO, Aberle LG, Lin M, Myles SK, Melloni C, Harrington RA, Alexander JH, Becker RC, Rusconi CP. Dyke CK, et al. Among authors: becker rc. Circulation. 2006 Dec 5;114(23):2490-7. doi: 10.1161/CIRCULATIONAHA.106.668434. Epub 2006 Nov 13. Circulation. 2006. PMID: 17101847 Clinical Trial.
Factor IXa inhibitors as novel anticoagulants.
Howard EL, Becker KC, Rusconi CP, Becker RC. Howard EL, et al. Among authors: becker rc, becker kc. Arterioscler Thromb Vasc Biol. 2007 Apr;27(4):722-7. doi: 10.1161/01.ATV.0000259363.91070.f1. Epub 2007 Feb 1. Arterioscler Thromb Vasc Biol. 2007. PMID: 17272750 Review.
Platelet function monitoring in patients with coronary artery disease.
Gurbel PA, Becker RC, Mann KG, Steinhubl SR, Michelson AD. Gurbel PA, et al. Among authors: becker rc. J Am Coll Cardiol. 2007 Nov 6;50(19):1822-34. doi: 10.1016/j.jacc.2007.07.051. Epub 2007 Oct 23. J Am Coll Cardiol. 2007. PMID: 17980247 Free article. Review.
Incidence and prognostic significance of thrombocytopenia in patients treated with prolonged heparin therapy.
Oliveira GB, Crespo EM, Becker RC, Honeycutt EF, Abrams CS, Anstrom KJ, Berger PB, Davidson-Ray LD, Eisenstein EL, Kleiman NS, Moliterno DJ, Moll S, Rice L, Rodgers JE, Steinhubl SR, Tapson VF, Ohman EM, Granger CB; Complications After Thrombocytopenia Caused by Heparin (CATCH) Registry Investigators. Oliveira GB, et al. Among authors: becker rc. Arch Intern Med. 2008 Jan 14;168(1):94-102. doi: 10.1001/archinternmed.2007.65. Arch Intern Med. 2008. PMID: 18195201
Phase 1b randomized study of antidote-controlled modulation of factor IXa activity in patients with stable coronary artery disease.
Chan MY, Cohen MG, Dyke CK, Myles SK, Aberle LG, Lin M, Walder J, Steinhubl SR, Gilchrist IC, Kleiman NS, Vorchheimer DA, Chronos N, Melloni C, Alexander JH, Harrington RA, Tonkens RM, Becker RC, Rusconi CP. Chan MY, et al. Among authors: becker rc. Circulation. 2008 Jun 3;117(22):2865-74. doi: 10.1161/CIRCULATIONAHA.107.745687. Epub 2008 May 27. Circulation. 2008. PMID: 18506005 Clinical Trial.
585 results