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The viral oncogene Np9 acts as a critical molecular switch for co-activating β-catenin, ERK, Akt and Notch1 and promoting the growth of human leukemia stem/progenitor cells.
Chen T, Meng Z, Gan Y, Wang X, Xu F, Gu Y, Xu X, Tang J, Zhou H, Zhang X, Gan X, Van Ness C, Xu G, Huang L, Zhang X, Fang Y, Wu J, Zheng S, Jin J, Huang W, Xu R. Chen T, et al. Among authors: xu r, xu f, xu g, xu x. Leukemia. 2013 Jul;27(7):1469-78. doi: 10.1038/leu.2013.8. Epub 2013 Jan 11. Leukemia. 2013. PMID: 23307033
Phase I and biodistribution study of recombinant adenovirus vector-mediated herpes simplex virus thymidine kinase gene and ganciclovir administration in patients with head and neck cancer and other malignant tumors.
Xu F, Li S, Li XL, Guo Y, Zou BY, Xu R, Liao H, Zhao HY, Zhang Y, Guan ZZ, Zhang L. Xu F, et al. Among authors: xu r. Cancer Gene Ther. 2009 Sep;16(9):723-30. doi: 10.1038/cgt.2009.19. Epub 2009 Apr 10. Cancer Gene Ther. 2009. PMID: 19363470 Clinical Trial.
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