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Angiogenesis is regulated by a novel mechanism: pro- and antiangiogenic proteins are organized into separate platelet alpha granules and differentially released.
Italiano JE Jr, Richardson JL, Patel-Hett S, Battinelli E, Zaslavsky A, Short S, Ryeom S, Folkman J, Klement GL. Italiano JE Jr, et al. Among authors: klement gl. Blood. 2008 Feb 1;111(3):1227-33. doi: 10.1182/blood-2007-09-113837. Epub 2007 Oct 25. Blood. 2008. PMID: 17962514 Free PMC article.
Platelets actively sequester angiogenesis regulators.
Klement GL, Yip TT, Cassiola F, Kikuchi L, Cervi D, Podust V, Italiano JE, Wheatley E, Abou-Slaybi A, Bender E, Almog N, Kieran MW, Folkman J. Klement GL, et al. Blood. 2009 Mar 19;113(12):2835-42. doi: 10.1182/blood-2008-06-159541. Epub 2008 Nov 25. Blood. 2009. PMID: 19036702 Free PMC article.
Platelet-associated PF-4 as a biomarker of early tumor growth.
Cervi D, Yip TT, Bhattacharya N, Podust VN, Peterson J, Abou-Slaybi A, Naumov GN, Bender E, Almog N, Italiano JE Jr, Folkman J, Klement GL. Cervi D, et al. Among authors: klement gl. Blood. 2008 Feb 1;111(3):1201-7. doi: 10.1182/blood-2007-04-084798. Epub 2007 Oct 3. Blood. 2008. PMID: 17914028 Free article.
VEGF, PF4 and PDGF are elevated in platelets of colorectal cancer patients.
Peterson JE, Zurakowski D, Italiano JE Jr, Michel LV, Connors S, Oenick M, D'Amato RJ, Klement GL, Folkman J. Peterson JE, et al. Among authors: klement gl. Angiogenesis. 2012 Jun;15(2):265-73. doi: 10.1007/s10456-012-9259-z. Epub 2012 Mar 9. Angiogenesis. 2012. PMID: 22402885 Clinical Trial.
56 results