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Conversion of the Alzheimer's beta-amyloid precursor protein (APP) Kunitz domain into a potent human neutrophil elastase inhibitor.
Sinha S, Knops J, Esch F, Moyer ED, Oltersdorf T. Sinha S, et al. J Biol Chem. 1991 Nov 5;266(31):21011-3. J Biol Chem. 1991. PMID: 1939150 Free article.
Site-specific mutagenesis techniques have been used to construct active site variants of the Kunitz-type protease inhibitor domain present in the Alzheimer's beta-amyloid precursor protein (APP-KD). Striking alteration of its protease inhibitory properties were obtained wh …
Site-specific mutagenesis techniques have been used to construct active site variants of the Kunitz-type protease inhibitor domain present i …
6,512 results