Erion MD - Search Results

1

Reduction of hepatic steatosis in rats and mice after treatment with a liver-targeted thyroid hormone receptor agonist.

Cable EE, Finn PD, Stebbins JW, Hou J, Ito BR, van Poelje PD, Linemeyer DL, Erion MD. Cable EE, et al. Among authors: erion md. Hepatology. 2009 Feb;49(2):407-17. doi: 10.1002/hep.22572. Hepatology. 2009. PMID: 19072834

2

Targeting thyroid hormone receptor-beta agonists to the liver reduces cholesterol and triglycerides and improves the therapeutic index.

Erion MD, Cable EE, Ito BR, Jiang H, Fujitaki JM, Finn PD, Zhang BH, Hou J, Boyer SH, van Poelje PD, Linemeyer DL. Erion MD, et al. Proc Natl Acad Sci U S A. 2007 Sep 25;104(39):15490-5. doi: 10.1073/pnas.0702759104. Epub 2007 Sep 18. Proc Natl Acad Sci U S A. 2007. PMID: 17878314 Free PMC article.

3

Preclinical pharmacokinetics of a HepDirect prodrug of a novel phosphonate-containing thyroid hormone receptor agonist.

Fujitaki JM, Cable EE, Ito BR, Zhang BH, Hou J, Yang C, Bullough DA, Ferrero JL, van Poelje PD, Linemeyer DL, Erion MD. Fujitaki JM, et al. Among authors: erion md. Drug Metab Dispos. 2008 Nov;36(11):2393-403. doi: 10.1124/dmd.108.021642. Epub 2008 Aug 14. Drug Metab Dispos. 2008. PMID: 18703645

4

Synthesis and biological evaluation of a series of liver-selective phosphonic acid thyroid hormone receptor agonists and their prodrugs.

Boyer SH, Jiang H, Jacintho JD, Reddy MV, Li H, Li W, Godwin JL, Schulz WG, Cable EE, Hou J, Wu R, Fujitaki JM, Hecker SJ, Erion MD. Boyer SH, et al. Among authors: erion md. J Med Chem. 2008 Nov 27;51(22):7075-93. doi: 10.1021/jm800824d. J Med Chem. 2008. PMID: 18975928

5

Thyroid hormone beta receptor activation has additive cholesterol lowering activity in combination with atorvastatin in rabbits, dogs and monkeys.

Ito BR, Zhang BH, Cable EE, Song X, Fujitaki JM, MacKenna DA, Wilker CE, Chi B, van Poelje PD, Linemeyer DL, Erion MD. Ito BR, et al. Among authors: erion md. Br J Pharmacol. 2009 Feb;156(3):454-65. doi: 10.1111/j.1750-3639.2009.00038.x. Epub 2009 Jan 22. Br J Pharmacol. 2009. PMID: 19183199 Free PMC article.

6

Liver-targeted drug delivery using HepDirect prodrugs.

Erion MD, van Poelje PD, Mackenna DA, Colby TJ, Montag AC, Fujitaki JM, Linemeyer DL, Bullough DA. Erion MD, et al. J Pharmacol Exp Ther. 2005 Feb;312(2):554-60. doi: 10.1124/jpet.104.075903. Epub 2004 Aug 31. J Pharmacol Exp Ther. 2005. PMID: 15340017

7

Liver targeting of hepatitis-B antiviral lamivudine using the HepDirect prodrug technology.

Reddy KR, Colby TJ, Fujitaki JM, van Poelje PD, Erion MD. Reddy KR, et al. Among authors: erion md. Nucleosides Nucleotides Nucleic Acids. 2005;24(5-7):375-81. doi: 10.1081/ncn-200059781. Nucleosides Nucleotides Nucleic Acids. 2005. PMID: 16247954

8

Liver-targeted prodrugs of 2'-C-methyladenosine for therapy of hepatitis C virus infection.

Hecker SJ, Reddy KR, van Poelje PD, Sun Z, Huang W, Varkhedkar V, Reddy MV, Fujitaki JM, Olsen DB, Koeplinger KA, Boyer SH, Linemeyer DL, MacCoss M, Erion MD. Hecker SJ, et al. Among authors: erion md. J Med Chem. 2007 Aug 9;50(16):3891-6. doi: 10.1021/jm0701021. Epub 2007 Jul 18. J Med Chem. 2007. PMID: 17636948

9

Discovery of fructose-1,6-bisphosphatase inhibitors for the treatment of type 2 diabetes.

van Poelje PD, Dang Q, Erion MD. van Poelje PD, et al. Among authors: erion md. Curr Opin Drug Discov Devel. 2007 Jul;10(4):430-7. Curr Opin Drug Discov Devel. 2007. PMID: 17659484 Review.

10

Pradefovir: a prodrug that targets adefovir to the liver for the treatment of hepatitis B.

Reddy KR, Matelich MC, Ugarkar BG, Gómez-Galeno JE, DaRe J, Ollis K, Sun Z, Craigo W, Colby TJ, Fujitaki JM, Boyer SH, van Poelje PD, Erion MD. Reddy KR, et al. Among authors: erion md. J Med Chem. 2008 Feb 14;51(3):666-76. doi: 10.1021/jm7012216. Epub 2008 Jan 4. J Med Chem. 2008. PMID: 18173234

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