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In vivo dynamics of stable chronic lymphocytic leukemia inversely correlate with somatic hypermutation levels and suggest no major leukemic turnover in bone marrow.
van Gent R, Kater AP, Otto SA, Jaspers A, Borghans JA, Vrisekoop N, Ackermans MA, Ruiter AF, Wittebol S, Eldering E, van Oers MH, Tesselaar K, Kersten MJ, Miedema F. van Gent R, et al. Among authors: miedema f. Cancer Res. 2008 Dec 15;68(24):10137-44. doi: 10.1158/0008-5472.CAN-08-2325. Cancer Res. 2008. PMID: 19074880
Quantification of naive and memory T-cell turnover during HIV-1 infection.
Vrisekoop N, Drylewicz J, Van Gent R, Mugwagwa T, Van Lelyveld SF, Veel E, Otto SA, Ackermans MT, Vermeulen JN, Huidekoper HH, Prins JM, Miedema F, de Boer RJ, Tesselaar K, Borghans JA. Vrisekoop N, et al. Among authors: miedema f. AIDS. 2015 Oct 23;29(16):2071-80. doi: 10.1097/QAD.0000000000000822. AIDS. 2015. PMID: 26213901
Limited role for the thymus in SIV pathogenesis.
Borghans JA, Hazenberg MD, Miedema F. Borghans JA, et al. Among authors: miedema f. Eur J Immunol. 2005 Jan;35(1):42-5. doi: 10.1002/eji.200425643. Eur J Immunol. 2005. PMID: 15593304 Free article. Review.
Sparse production but preferential incorporation of recently produced naive T cells in the human peripheral pool.
Vrisekoop N, den Braber I, de Boer AB, Ruiter AF, Ackermans MT, van der Crabben SN, Schrijver EH, Spierenburg G, Sauerwein HP, Hazenberg MD, de Boer RJ, Miedema F, Borghans JA, Tesselaar K. Vrisekoop N, et al. Among authors: miedema f. Proc Natl Acad Sci U S A. 2008 Apr 22;105(16):6115-20. doi: 10.1073/pnas.0709713105. Epub 2008 Apr 17. Proc Natl Acad Sci U S A. 2008. PMID: 18420820 Free PMC article.
Restoration of the CD4 T cell compartment after long-term highly active antiretroviral therapy without phenotypical signs of accelerated immunological aging.
Vrisekoop N, van Gent R, de Boer AB, Otto SA, Borleffs JC, Steingrover R, Prins JM, Kuijpers TW, Wolfs TF, Geelen SP, Vulto I, Lansdorp P, Tesselaar K, Borghans JA, Miedema F. Vrisekoop N, et al. Among authors: miedema f. J Immunol. 2008 Jul 15;181(2):1573-81. doi: 10.4049/jimmunol.181.2.1573. J Immunol. 2008. PMID: 18606713
Maintenance of peripheral naive T cells is sustained by thymus output in mice but not humans.
den Braber I, Mugwagwa T, Vrisekoop N, Westera L, Mögling R, de Boer AB, Willems N, Schrijver EH, Spierenburg G, Gaiser K, Mul E, Otto SA, Ruiter AF, Ackermans MT, Miedema F, Borghans JA, de Boer RJ, Tesselaar K. den Braber I, et al. Among authors: miedema f. Immunity. 2012 Feb 24;36(2):288-97. doi: 10.1016/j.immuni.2012.02.006. Immunity. 2012. PMID: 22365666 Free article.
Immune activation and collateral damage in AIDS pathogenesis.
Miedema F, Hazenberg MD, Tesselaar K, van Baarle D, de Boer RJ, Borghans JA. Miedema F, et al. Front Immunol. 2013 Sep 26;4:298. doi: 10.3389/fimmu.2013.00298. Front Immunol. 2013. PMID: 24133492 Free PMC article. Review.
321 results