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Enhanced antitumor activity induced by adoptive T-cell transfer and adjunctive use of the histone deacetylase inhibitor LAQ824.
Vo DD, Prins RM, Begley JL, Donahue TR, Morris LF, Bruhn KW, de la Rocha P, Yang MY, Mok S, Garban HJ, Craft N, Economou JS, Marincola FM, Wang E, Ribas A. Vo DD, et al. Among authors: donahue tr. Cancer Res. 2009 Nov 15;69(22):8693-9. doi: 10.1158/0008-5472.CAN-09-1456. Epub 2009 Oct 27. Cancer Res. 2009. PMID: 19861533 Free PMC article.
Integrative survival-based molecular profiling of human pancreatic cancer.
Donahue TR, Tran LM, Hill R, Li Y, Kovochich A, Calvopina JH, Patel SG, Wu N, Hindoyan A, Farrell JJ, Li X, Dawson DW, Wu H. Donahue TR, et al. Clin Cancer Res. 2012 Mar 1;18(5):1352-63. doi: 10.1158/1078-0432.CCR-11-1539. Epub 2012 Jan 18. Clin Cancer Res. 2012. PMID: 22261810 Free PMC article.
Durable Suppression of Acquired MEK Inhibitor Resistance in Cancer by Sequestering MEK from ERK and Promoting Antitumor T-cell Immunity.
Hong A, Piva M, Liu S, Hugo W, Lomeli SH, Zoete V, Randolph CE, Yang Z, Wang Y, Lee JJ, Lo SJ, Sun L, Vega-Crespo A, Garcia AJ, Shackelford DB, Dubinett SM, Scumpia PO, Byrum SD, Tackett AJ, Donahue TR, Michielin O, Holmen SL, Ribas A, Moriceau G, Lo RS. Hong A, et al. Among authors: donahue tr. Cancer Discov. 2021 Mar;11(3):714-735. doi: 10.1158/2159-8290.CD-20-0873. Epub 2020 Dec 14. Cancer Discov. 2021. PMID: 33318037 Free PMC article.
Purine nucleoside phosphorylase enables dual metabolic checkpoints that prevent T cell immunodeficiency and TLR7-associated autoimmunity.
Abt ER, Rashid K, Le TM, Li S, Lee HR, Lok V, Li L, Creech AL, Labora AN, Mandl HK, Lam AK, Cho A, Rezek V, Wu N, Abril-Rodriguez G, Rosser EW, Mittelman SD, Hugo W, Mehrling T, Bantia S, Ribas A, Donahue TR, Crooks GM, Wu TT, Radu CG. Abt ER, et al. Among authors: donahue tr. J Clin Invest. 2022 Aug 15;132(16):e160852. doi: 10.1172/JCI160852. J Clin Invest. 2022. PMID: 35653193 Free PMC article.
MEK Inhibition Sensitizes Pancreatic Cancer to STING Agonism by Tumor Cell-intrinsic Amplification of Type I IFN Signaling.
Ghukasyan R, Liang K, Chau K, Li L, Chan C, Abt ER, Le T, Park JY, Wu N, Premji A, Damoiseaux R, Luu T, Labora A, Rashid K, Link JM, Radu CG, Donahue TR. Ghukasyan R, et al. Among authors: donahue tr. Clin Cancer Res. 2023 Aug 15;29(16):3130-3141. doi: 10.1158/1078-0432.CCR-22-3322. Clin Cancer Res. 2023. PMID: 37195712 Free PMC article.
146 results