Schuler G - Search Results

1

Transfer of mRNA encoding recombinant immunoreceptors reprograms CD4+ and CD8+ T cells for use in the adoptive immunotherapy of cancer.

Birkholz K, Hombach A, Krug C, Reuter S, Kershaw M, Kämpgen E, Schuler G, Abken H, Schaft N, Dörrie J. Birkholz K, et al. Among authors: schuler g. Gene Ther. 2009 May;16(5):596-604. doi: 10.1038/gt.2008.189. Epub 2009 Jan 22. Gene Ther. 2009. PMID: 19158846

2

A GMP-compliant protocol to expand and transfect cancer patient T cells with mRNA encoding a tumor-specific chimeric antigen receptor.

Krug C, Wiesinger M, Abken H, Schuler-Thurner B, Schuler G, Dörrie J, Schaft N. Krug C, et al. Among authors: schuler g, schuler thurner b. Cancer Immunol Immunother. 2014 Oct;63(10):999-1008. doi: 10.1007/s00262-014-1572-5. Epub 2014 Jun 18. Cancer Immunol Immunother. 2014. PMID: 24938475 Free PMC article.

3

A new method to monitor antigen-specific CD8+ T cells, avoiding additional target cells and the restriction to human leukocyte antigen haplotype.

Prommersberger S, Höfflin S, Schuler-Thurner B, Schuler G, Schaft N, Dörrie J. Prommersberger S, et al. Among authors: schuler g, schuler thurner b. Gene Ther. 2015 Jun;22(6):516-20. doi: 10.1038/gt.2015.15. Epub 2015 Mar 19. Gene Ther. 2015. PMID: 25786872

4

Generation of an optimized polyvalent monocyte-derived dendritic cell vaccine by transfecting defined RNAs after rather than before maturation.

Schaft N, Dörrie J, Thumann P, Beck VE, Müller I, Schultz ES, Kämpgen E, Dieckmann D, Schuler G. Schaft N, et al. Among authors: schuler g. J Immunol. 2005 Mar 1;174(5):3087-97. doi: 10.4049/jimmunol.174.5.3087. J Immunol. 2005. PMID: 15728524

5

A new way to generate cytolytic tumor-specific T cells: electroporation of RNA coding for a T cell receptor into T lymphocytes.

Schaft N, Dörrie J, Müller I, Beck V, Baumann S, Schunder T, Kämpgen E, Schuler G. Schaft N, et al. Among authors: schuler g. Cancer Immunol Immunother. 2006 Sep;55(9):1132-41. doi: 10.1007/s00262-005-0098-2. Epub 2005 Dec 13. Cancer Immunol Immunother. 2006. PMID: 16344988 Free PMC article.

6

Effective clinical-scale production of dendritic cell vaccines by monocyte elutriation directly in medium, subsequent culture in bags and final antigen loading using peptides or RNA transfection.

Erdmann M, Dörrie J, Schaft N, Strasser E, Hendelmeier M, Kämpgen E, Schuler G, Schuler-Thurner B. Erdmann M, et al. Among authors: schuler g, schuler thurner b. J Immunother. 2007 Sep;30(6):663-74. doi: 10.1097/CJI.0b013e3180ca7cd6. J Immunother. 2007. PMID: 17667530

7

Introduction of functional chimeric E/L-selectin by RNA electroporation to target dendritic cells from blood to lymph nodes.

Dörrie J, Schaft N, Müller I, Wellner V, Schunder T, Hänig J, Oostingh GJ, Schön MP, Robert C, Kämpgen E, Schuler G. Dörrie J, et al. Among authors: schuler g. Cancer Immunol Immunother. 2008 Apr;57(4):467-77. doi: 10.1007/s00262-007-0385-1. Epub 2007 Sep 2. Cancer Immunol Immunother. 2008. PMID: 17768622 Free PMC article.

8

Generation of HIV-1-specific T cells by electroporation of T-cell receptor RNA.

Hofmann C, Harrer T, Kubesch V, Maurer K, Metzner KJ, Eismann K, Bergmann S, Schmitt-Haendle M, Schuler G, Dörrie J, Schaft N. Hofmann C, et al. Among authors: schuler g. AIDS. 2008 Aug 20;22(13):1577-82. doi: 10.1097/QAD.0b013e3283063a17. AIDS. 2008. PMID: 18670216

9

A fast and robust method to clone and functionally validate T-cell receptors.

Birkholz K, Hofmann C, Hoyer S, Schulz B, Harrer T, Kämpgen E, Schuler G, Dörrie J, Schaft N. Birkholz K, et al. Among authors: schuler g. J Immunol Methods. 2009 Jul 31;346(1-2):45-54. doi: 10.1016/j.jim.2009.05.001. Epub 2009 May 7. J Immunol Methods. 2009. PMID: 19427315

10

Generation of human dendritic cells that simultaneously secrete IL-12 and have migratory capacity by adenoviral gene transfer of hCD40L in combination with IFN-gamma.

Knippertz I, Hesse A, Schunder T, Kämpgen E, Brenner MK, Schuler G, Steinkasserer A, Nettelbeck DM. Knippertz I, et al. Among authors: schuler g. J Immunother. 2009 Jun;32(5):524-38. doi: 10.1097/CJI.0b013e3181a28422. J Immunother. 2009. PMID: 19609245

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