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The HA and NS genes of human H5N1 influenza A virus contribute to high virulence in ferrets.
Imai H, Shinya K, Takano R, Kiso M, Muramoto Y, Sakabe S, Murakami S, Ito M, Yamada S, Le MT, Nidom CA, Sakai-Tagawa Y, Takahashi K, Omori Y, Noda T, Shimojima M, Kakugawa S, Goto H, Iwatsuki-Horimoto K, Horimoto T, Kawaoka Y. Imai H, et al. Among authors: takano r. PLoS Pathog. 2010 Sep 16;6(9):e1001106. doi: 10.1371/journal.ppat.1001106. PLoS Pathog. 2010. PMID: 20862325 Free PMC article.
Avian-type receptor-binding ability can increase influenza virus pathogenicity in macaques.
Watanabe T, Shinya K, Watanabe S, Imai M, Hatta M, Li C, Wolter BF, Neumann G, Hanson A, Ozawa M, Yamada S, Imai H, Sakabe S, Takano R, Iwatsuki-Horimoto K, Kiso M, Ito M, Fukuyama S, Kawakami E, Gorai T, Simmons HA, Schenkman D, Brunner K, Capuano SV 3rd, Weinfurter JT, Nishio W, Maniwa Y, Igarashi T, Makino A, Travanty EA, Wang J, Kilander A, Dudman SG, Suresh M, Mason RJ, Hungnes O, Friedrich TC, Kawaoka Y. Watanabe T, et al. Among authors: takano r. J Virol. 2011 Dec;85(24):13195-203. doi: 10.1128/JVI.00859-11. Epub 2011 Sep 21. J Virol. 2011. PMID: 21937653 Free PMC article.
Differences in cytokine production in human macrophages and in virulence in mice are attributable to the acidic polymerase protein of highly pathogenic influenza A virus subtype H5N1.
Sakabe S, Takano R, Nagamura-Inoue T, Yamashita N, Nidom CA, Quynh Le Mt, Iwatsuki-Horimoto K, Kawaoka Y. Sakabe S, et al. Among authors: takano r. J Infect Dis. 2013 Jan 15;207(2):262-71. doi: 10.1093/infdis/jis523. Epub 2012 Oct 4. J Infect Dis. 2013. PMID: 23042757 Free PMC article.
Virulence determinants of pandemic A(H1N1)2009 influenza virus in a mouse model.
Uraki R, Kiso M, Shinya K, Goto H, Takano R, Iwatsuki-Horimoto K, Takahashi K, Daniels RS, Hungnes O, Watanabe T, Kawaoka Y. Uraki R, et al. Among authors: takano r. J Virol. 2013 Feb;87(4):2226-33. doi: 10.1128/JVI.01565-12. Epub 2012 Dec 5. J Virol. 2013. PMID: 23221570 Free PMC article.
243 results