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Profound CD4+/CCR5+ T cell expansion is induced by CD8+ lymphocyte depletion but does not account for accelerated SIV pathogenesis.
Okoye A, Park H, Rohankhedkar M, Coyne-Johnson L, Lum R, Walker JM, Planer SL, Legasse AW, Sylwester AW, Piatak M Jr, Lifson JD, Sodora DL, Villinger F, Axthelm MK, Schmitz JE, Picker LJ. Okoye A, et al. Among authors: rohankhedkar m. J Exp Med. 2009 Jul 6;206(7):1575-88. doi: 10.1084/jem.20090356. Epub 2009 Jun 22. J Exp Med. 2009. PMID: 19546246 Free PMC article.
Progressive CD4+ central memory T cell decline results in CD4+ effector memory insufficiency and overt disease in chronic SIV infection.
Okoye A, Meier-Schellersheim M, Brenchley JM, Hagen SI, Walker JM, Rohankhedkar M, Lum R, Edgar JB, Planer SL, Legasse A, Sylwester AW, Piatak M Jr, Lifson JD, Maino VC, Sodora DL, Douek DC, Axthelm MK, Grossman Z, Picker LJ. Okoye A, et al. Among authors: rohankhedkar m. J Exp Med. 2007 Sep 3;204(9):2171-85. doi: 10.1084/jem.20070567. Epub 2007 Aug 27. J Exp Med. 2007. PMID: 17724130 Free PMC article.
Naive T cells are dispensable for memory CD4+ T cell homeostasis in progressive simian immunodeficiency virus infection.
Okoye AA, Rohankhedkar M, Abana C, Pattenn A, Reyes M, Pexton C, Lum R, Sylwester A, Planer SL, Legasse A, Park BS, Piatak M Jr, Lifson JD, Axthelm MK, Picker LJ. Okoye AA, et al. Among authors: rohankhedkar m. J Exp Med. 2012 Apr 9;209(4):641-51. doi: 10.1084/jem.20112071. Epub 2012 Mar 26. J Exp Med. 2012. PMID: 22451717 Free PMC article.
Effect of IL-7 Therapy on Naive and Memory T Cell Homeostasis in Aged Rhesus Macaques.
Okoye AA, Rohankhedkar M, Konfe AL, Abana CO, Reyes MD, Clock JA, Duell DM, Sylwester AW, Sammader P, Legasse AW, Park BS, Axthelm MK, Nikolich-Žugich J, Picker LJ. Okoye AA, et al. Among authors: rohankhedkar m. J Immunol. 2015 Nov 1;195(9):4292-305. doi: 10.4049/jimmunol.1500609. Epub 2015 Sep 28. J Immunol. 2015. PMID: 26416281 Free PMC article.
Increased CD4+ T cell levels during IL-7 administration of antiretroviral therapy-treated simian immunodeficiency virus-positive macaques are not dependent on strong proliferative responses.
Leone A, Rohankhedkar M, Okoye A, Legasse A, Axthelm MK, Villinger F, Piatak M Jr, Lifson JD, Assouline B, Morre M, Picker LJ, Sodora DL. Leone A, et al. Among authors: rohankhedkar m. J Immunol. 2010 Aug 1;185(3):1650-9. doi: 10.4049/jimmunol.0902626. Epub 2010 Jul 9. J Immunol. 2010. PMID: 20622118 Free PMC article.