McIntosh JM - Search Results

1

Structural basis for alpha-conotoxin potency and selectivity.

Turner M, Eidemiller S, Martin B, Narver A, Marshall J, Zemp L, Cornell KA, McIntosh JM, McDougal OM. Turner M, et al. Among authors: mcintosh jm. Bioorg Med Chem. 2009 Aug 15;17(16):5894-9. doi: 10.1016/j.bmc.2009.07.005. Epub 2009 Jul 9. Bioorg Med Chem. 2009. PMID: 19628399 Free PMC article.

2

Characterization of a novel α-conotoxin TxID from Conus textile that potently blocks rat α3β4 nicotinic acetylcholine receptors.

Luo S, Zhangsun D, Zhu X, Wu Y, Hu Y, Christensen S, Harvey PJ, Akcan M, Craik DJ, McIntosh JM. Luo S, et al. Among authors: mcintosh jm. J Med Chem. 2013 Dec 12;56(23):9655-63. doi: 10.1021/jm401254c. Epub 2013 Nov 22. J Med Chem. 2013. PMID: 24200193 Free PMC article.

3

Discovery of a potent and selective α3β4 nicotinic acetylcholine receptor antagonist from an α-conotoxin synthetic combinatorial library.

Chang YP, Banerjee J, Dowell C, Wu J, Gyanda R, Houghten RA, Toll L, McIntosh JM, Armishaw CJ. Chang YP, et al. Among authors: mcintosh jm. J Med Chem. 2014 Apr 24;57(8):3511-21. doi: 10.1021/jm500183r. Epub 2014 Apr 3. J Med Chem. 2014. PMID: 24649848 Free PMC article.

4

Definition of the M-conotoxin superfamily: characterization of novel peptides from molluscivorous Conus venoms.

Corpuz GP, Jacobsen RB, Jimenez EC, Watkins M, Walker C, Colledge C, Garrett JE, McDougal O, Li W, Gray WR, Hillyard DR, Rivier J, McIntosh JM, Cruz LJ, Olivera BM. Corpuz GP, et al. Among authors: mcintosh jm. Biochemistry. 2005 Jun 7;44(22):8176-86. doi: 10.1021/bi047541b. Biochemistry. 2005. PMID: 15924437

5

Amino acid residues that confer high selectivity of the alpha6 nicotinic acetylcholine receptor subunit to alpha-conotoxin MII[S4A,E11A,L15A].

Azam L, Yoshikami D, McIntosh JM. Azam L, et al. Among authors: mcintosh jm. J Biol Chem. 2008 Apr 25;283(17):11625-32. doi: 10.1074/jbc.M710288200. Epub 2008 Feb 25. J Biol Chem. 2008. PMID: 18299323 Free PMC article.

6

α-Conotoxin [S9A]TxID Potently Discriminates between α3β4 and α6/α3β4 Nicotinic Acetylcholine Receptors.

Wu Y, Zhangsun D, Zhu X, Kaas Q, Zhangsun M, Harvey PJ, Craik DJ, McIntosh JM, Luo S. Wu Y, et al. Among authors: mcintosh jm. J Med Chem. 2017 Jul 13;60(13):5826-5833. doi: 10.1021/acs.jmedchem.7b00546. Epub 2017 Jun 21. J Med Chem. 2017. PMID: 28603989 Free PMC article.

7

Positional scanning mutagenesis of α-conotoxin PeIA identifies critical residues that confer potency and selectivity for α6/α3β2β3 and α3β2 nicotinic acetylcholine receptors.

Hone AJ, Ruiz M, Scadden M, Christensen S, Gajewiak J, Azam L, McIntosh JM. Hone AJ, et al. Among authors: mcintosh jm. J Biol Chem. 2013 Aug 30;288(35):25428-25439. doi: 10.1074/jbc.M113.482059. Epub 2013 Jul 11. J Biol Chem. 2013. PMID: 23846688 Free PMC article.

8

Discovery of Methylene Thioacetal-Incorporated α-RgIA Analogues as Potent and Stable Antagonists of the Human α9α10 Nicotinic Acetylcholine Receptor for the Treatment of Neuropathic Pain.

Zheng N, Christensen SB, Dowell C, Purushottam L, Skalicky JJ, McIntosh JM, Chou DH. Zheng N, et al. Among authors: mcintosh jm. J Med Chem. 2021 Jul 8;64(13):9513-9524. doi: 10.1021/acs.jmedchem.1c00802. Epub 2021 Jun 23. J Med Chem. 2021. PMID: 34161094 Free PMC article.

9

Development of Conformationally Constrained α-RgIA Analogues as Stable Peptide Antagonists of Human α9α10 Nicotinic Acetylcholine Receptors.

Zheng N, Christensen SB, Blakely A, Dowell C, Purushottam L, McIntosh JM, Chou DH. Zheng N, et al. Among authors: mcintosh jm. J Med Chem. 2020 Aug 13;63(15):8380-8387. doi: 10.1021/acs.jmedchem.0c00613. Epub 2020 Jul 16. J Med Chem. 2020. PMID: 32597184 Free PMC article.

10

Methyllycaconitine is a potent antagonist of alpha-conotoxin-MII-sensitive presynaptic nicotinic acetylcholine receptors in rat striatum.

Mogg AJ, Whiteaker P, McIntosh JM, Marks M, Collins AC, Wonnacott S. Mogg AJ, et al. Among authors: mcintosh jm. J Pharmacol Exp Ther. 2002 Jul;302(1):197-204. doi: 10.1124/jpet.302.1.197. J Pharmacol Exp Ther. 2002. PMID: 12065717

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