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Page 1
The discovery and optimisation of pyrido[2,3-d]pyrimidine-2,4-diamines as potent and selective inhibitors of mTOR kinase.
Malagu K, Duggan H, Menear K, Hummersone M, Gomez S, Bailey C, Edwards P, Drzewiecki J, Leroux F, Quesada MJ, Hermann G, Maine S, Molyneaux CA, Le Gall A, Pullen J, Hickson I, Smith L, Maguire S, Martin N, Smith G, Pass M. Malagu K, et al. Among authors: bailey c. Bioorg Med Chem Lett. 2009 Oct 15;19(20):5950-3. doi: 10.1016/j.bmcl.2009.08.038. Epub 2009 Aug 13. Bioorg Med Chem Lett. 2009. PMID: 19762236
Identification and optimisation of novel and selective small molecular weight kinase inhibitors of mTOR.
Menear KA, Gomez S, Malagu K, Bailey C, Blackburn K, Cockcroft XL, Ewen S, Fundo A, Le Gall A, Hermann G, Sebastian L, Sunose M, Presnot T, Torode E, Hickson I, Martin NM, Smith GC, Pike KG. Menear KA, et al. Among authors: bailey c. Bioorg Med Chem Lett. 2009 Oct 15;19(20):5898-901. doi: 10.1016/j.bmcl.2009.08.069. Epub 2009 Aug 21. Bioorg Med Chem Lett. 2009. PMID: 19733066
1-substituted (Dibenzo[b,d]thiophen-4-yl)-2-morpholino-4H-chromen-4-ones endowed with dual DNA-PK/PI3-K inhibitory activity.
Cano C, Saravanan K, Bailey C, Bardos J, Curtin NJ, Frigerio M, Golding BT, Hardcastle IR, Hummersone MG, Menear KA, Newell DR, Richardson CJ, Shea K, Smith GC, Thommes P, Ting A, Griffin RJ. Cano C, et al. Among authors: bailey c. J Med Chem. 2013 Aug 22;56(16):6386-401. doi: 10.1021/jm400915j. Epub 2013 Aug 1. J Med Chem. 2013. PMID: 23855836
DNA-dependent protein kinase (DNA-PK) inhibitors. Synthesis and biological activity of quinolin-4-one and pyridopyrimidin-4-one surrogates for the chromen-4-one chemotype.
Cano C, Barbeau OR, Bailey C, Cockcroft XL, Curtin NJ, Duggan H, Frigerio M, Golding BT, Hardcastle IR, Hummersone MG, Knights C, Menear KA, Newell DR, Richardson CJ, Smith GC, Spittle B, Griffin RJ. Cano C, et al. Among authors: bailey c. J Med Chem. 2010 Dec 23;53(24):8498-507. doi: 10.1021/jm100608j. Epub 2010 Nov 16. J Med Chem. 2010. PMID: 21080722
Biased signalling in analgesic research and development.
Conibear A, Bailey CP, Kelly E. Conibear A, et al. Among authors: bailey cp. Curr Opin Pharmacol. 2024 Jun 2;76:102465. doi: 10.1016/j.coph.2024.102465. Online ahead of print. Curr Opin Pharmacol. 2024. PMID: 38830321 Review.
Rationale, conceptual issues, and resultant protocol for a mixed methods Person Trade Off (PTO) and qualitative study to estimate and understand the relative value of gains in health for children and young people compared to adults.
Peasgood T, Bailey C, Chen G, De Silva A, De Silva Perera U, Norman R, Shah K, Viney R, Devlin N. Peasgood T, et al. Among authors: bailey c. PLoS One. 2024 Jun 3;19(6):e0302886. doi: 10.1371/journal.pone.0302886. eCollection 2024. PLoS One. 2024. PMID: 38829857 Free article.
Topping-Off a Long Thoracic Stabilization With Semi-Rigid Constructs May Have Favorable Biomechanical Effects to Prevent Proximal Junctional Kyphosis: A Biomechanical Comparison.
Cadieux C, Brzozowski P, Fernandes RJR, McGregor ME, Zdero R, Bailey CS, McLachlin SD, Rasoulinejad P. Cadieux C, et al. Among authors: bailey cs. Global Spine J. 2024 Jun 3:21925682241259695. doi: 10.1177/21925682241259695. Online ahead of print. Global Spine J. 2024. PMID: 38828634 Free article.
Representation of genomic intratumor heterogeneity in multi-region non-small cell lung cancer patient-derived xenograft models.
Hynds RE, Huebner A, Pearce DR, Hill MS, Akarca AU, Moore DA, Ward S, Gowers KHC, Karasaki T, Al Bakir M, Wilson GA, Pich O, Martínez-Ruiz C, Hossain ASMM, Pearce SP, Sivakumar M, Ben Aissa A, Grönroos E, Chandrasekharan D, Kolluri KK, Towns R, Wang K, Cook DE, Bosshard-Carter L, Naceur-Lombardelli C, Rowan AJ, Veeriah S, Litchfield K, Crosbie PAJ, Dive C, Quezada SA, Janes SM, Jamal-Hanjani M, Marafioti T; TRACERx consortium; McGranahan N, Swanton C. Hynds RE, et al. Nat Commun. 2024 May 31;15(1):4653. doi: 10.1038/s41467-024-47547-3. Nat Commun. 2024. PMID: 38821942 Free PMC article.
Real-world service costs for neovascular-AMD clinics in the United Kingdom: structured literature review and scenario analysis.
Sivaprasad S, Bailey C, Downey L, Gilbert R, Gale R, Kotagiri A, Mahmood S, Morgan-Warren P, Napier J, Narendran N, Pearce I, Rennie C, Talks J, Wojcik R, Jandhyala R. Sivaprasad S, et al. Among authors: bailey c. Curr Med Res Opin. 2024 May 30:1-21. doi: 10.1080/03007995.2024.2362278. Online ahead of print. Curr Med Res Opin. 2024. PMID: 38814914
3,223 results