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The discovery and optimisation of pyrido[2,3-d]pyrimidine-2,4-diamines as potent and selective inhibitors of mTOR kinase.
Bioorg Med Chem Lett. 2009 Oct 15;19(20):5950-3. doi: 10.1016/j.bmcl.2009.08.038. Epub 2009 Aug 13.
Bioorg Med Chem Lett. 2009.
PMID: 19762236
A covalent fragment-based strategy targeting a novel cysteine to inhibit activity of mutant EGFR kinase.
Kuki N, Walmsley DL, Kanai K, Takechi S, Yoshida M, Murakami R, Takano K, Tominaga Y, Takahashi M, Ito S, Nakao N, Angove H, Baker LM, Carter E, Dokurno P, Le Strat L, Macias AT, Molyneaux CA, Murray JB, Surgenor AE, Hamada T, Hubbard RE.
Kuki N, et al. Among authors: molyneaux ca.
RSC Med Chem. 2023 Oct 19;14(12):2731-2737. doi: 10.1039/d3md00439b. eCollection 2023 Dec 13.
RSC Med Chem. 2023.
PMID: 38107172
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Arylpiperazines displaying preferential potency against chloroquine-resistant strains of the malaria parasite Plasmodium falciparum.
Molyneaux CA, Krugliak M, Ginsburg H, Chibale K.
Molyneaux CA, et al.
Biochem Pharmacol. 2005 Dec 19;71(1-2):61-8. doi: 10.1016/j.bcp.2005.10.023. Epub 2005 Nov 18.
Biochem Pharmacol. 2005.
PMID: 16298348
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