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Induction of autophagy by spermidine promotes longevity.
Eisenberg T, Knauer H, Schauer A, Büttner S, Ruckenstuhl C, Carmona-Gutierrez D, Ring J, Schroeder S, Magnes C, Antonacci L, Fussi H, Deszcz L, Hartl R, Schraml E, Criollo A, Megalou E, Weiskopf D, Laun P, Heeren G, Breitenbach M, Grubeck-Loebenstein B, Herker E, Fahrenkrog B, Fröhlich KU, Sinner F, Tavernarakis N, Minois N, Kroemer G, Madeo F. Eisenberg T, et al. Among authors: heeren g. Nat Cell Biol. 2009 Nov;11(11):1305-14. doi: 10.1038/ncb1975. Epub 2009 Oct 4. Nat Cell Biol. 2009. PMID: 19801973
The mitochondrial ribosomal protein of the large subunit, Afo1p, determines cellular longevity through mitochondrial back-signaling via TOR1.
Heeren G, Rinnerthaler M, Laun P, von Seyerl P, Kössler S, Klinger H, Hager M, Bogengruber E, Jarolim S, Simon-Nobbe B, Schüller C, Carmona-Gutierrez D, Breitenbach-Koller L, Mück C, Jansen-Dürr P, Criollo A, Kroemer G, Madeo F, Breitenbach M. Heeren G, et al. Aging (Albany NY). 2009 Jul 13;1(7):622-36. doi: 10.18632/aging.100065. Aging (Albany NY). 2009. PMID: 20157544 Free PMC article.
MMI1 (YKL056c, TMA19), the yeast orthologue of the translationally controlled tumor protein (TCTP) has apoptotic functions and interacts with both microtubules and mitochondria.
Rinnerthaler M, Jarolim S, Heeren G, Palle E, Perju S, Klinger H, Bogengruber E, Madeo F, Braun RJ, Breitenbach-Koller L, Breitenbach M, Laun P. Rinnerthaler M, et al. Among authors: heeren g. Biochim Biophys Acta. 2006 May-Jun;1757(5-6):631-8. doi: 10.1016/j.bbabio.2006.05.022. Epub 2006 May 20. Biochim Biophys Acta. 2006. PMID: 16806052 Free article.
Yeast as a model for chronological and reproductive aging - a comparison.
Laun P, Rinnerthaler M, Bogengruber E, Heeren G, Breitenbach M. Laun P, et al. Among authors: heeren g. Exp Gerontol. 2006 Dec;41(12):1208-12. doi: 10.1016/j.exger.2006.11.001. Epub 2006 Nov 28. Exp Gerontol. 2006. PMID: 17126512 Review. No abstract available.
Superoxide radicals have a protective role during H2O2 stress.
Thorpe GW, Reodica M, Davies MJ, Heeren G, Jarolim S, Pillay B, Breitenbach M, Higgins VJ, Dawes IW. Thorpe GW, et al. Among authors: heeren g. Mol Biol Cell. 2013 Sep;24(18):2876-84. doi: 10.1091/mbc.E13-01-0052. Epub 2013 Jul 17. Mol Biol Cell. 2013. PMID: 23864711 Free PMC article.
Yno1p/Aim14p, a NADPH-oxidase ortholog, controls extramitochondrial reactive oxygen species generation, apoptosis, and actin cable formation in yeast.
Rinnerthaler M, Büttner S, Laun P, Heeren G, Felder TK, Klinger H, Weinberger M, Stolze K, Grousl T, Hasek J, Benada O, Frydlova I, Klocker A, Simon-Nobbe B, Jansko B, Breitenbach-Koller H, Eisenberg T, Gourlay CW, Madeo F, Burhans WC, Breitenbach M. Rinnerthaler M, et al. Among authors: heeren g. Proc Natl Acad Sci U S A. 2012 May 29;109(22):8658-63. doi: 10.1073/pnas.1201629109. Epub 2012 May 14. Proc Natl Acad Sci U S A. 2012. PMID: 22586098 Free PMC article.
63 results