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Induction of autophagy by spermidine promotes longevity.
Eisenberg T, Knauer H, Schauer A, Büttner S, Ruckenstuhl C, Carmona-Gutierrez D, Ring J, Schroeder S, Magnes C, Antonacci L, Fussi H, Deszcz L, Hartl R, Schraml E, Criollo A, Megalou E, Weiskopf D, Laun P, Heeren G, Breitenbach M, Grubeck-Loebenstein B, Herker E, Fahrenkrog B, Fröhlich KU, Sinner F, Tavernarakis N, Minois N, Kroemer G, Madeo F. Eisenberg T, et al. Among authors: megalou e. Nat Cell Biol. 2009 Nov;11(11):1305-14. doi: 10.1038/ncb1975. Epub 2009 Oct 4. Nat Cell Biol. 2009. PMID: 19801973
Spermidine and resveratrol induce autophagy by distinct pathways converging on the acetylproteome.
Morselli E, Mariño G, Bennetzen MV, Eisenberg T, Megalou E, Schroeder S, Cabrera S, Bénit P, Rustin P, Criollo A, Kepp O, Galluzzi L, Shen S, Malik SA, Maiuri MC, Horio Y, López-Otín C, Andersen JS, Tavernarakis N, Madeo F, Kroemer G. Morselli E, et al. Among authors: megalou e. J Cell Biol. 2011 Feb 21;192(4):615-29. doi: 10.1083/jcb.201008167. J Cell Biol. 2011. PMID: 21339330 Free PMC article.
Spermidine promotes mating and fertilization efficiency in model organisms.
Bauer MA, Carmona-Gutiérrez D, Ruckenstuhl C, Reisenbichler A, Megalou EV, Eisenberg T, Magnes C, Jungwirth H, Sinner FM, Pieber TR, Fröhlich KU, Kroemer G, Tavernarakis N, Madeo F. Bauer MA, et al. Among authors: megalou ev. Cell Cycle. 2013 Jan 15;12(2):346-52. doi: 10.4161/cc.23199. Epub 2012 Jan 15. Cell Cycle. 2013. PMID: 23255134 Free PMC article.
Longevity-relevant regulation of autophagy at the level of the acetylproteome.
Mariño G, Morselli E, Bennetzen MV, Eisenberg T, Megalou E, Schroeder S, Cabrera S, Bénit P, Rustin P, Criollo A, Kepp O, Galluzzi L, Shen S, Malik SA, Maiuri MC, Horio Y, López-Otín C, Andersen JS, Tavernarakis N, Madeo F, Kroemer G. Mariño G, et al. Among authors: megalou e. Autophagy. 2011 Jun;7(6):647-9. doi: 10.4161/auto.7.6.15191. Epub 2011 Jun 1. Autophagy. 2011. PMID: 21460620 Free article.
Autophagy in Caenorhabditis elegans.
Megalou EV, Tavernarakis N. Megalou EV, et al. Biochim Biophys Acta. 2009 Sep;1793(9):1444-51. doi: 10.1016/j.bbamcr.2008.12.010. Epub 2008 Dec 25. Biochim Biophys Acta. 2009. PMID: 19150634 Free article. Review.
The life span-prolonging effect of sirtuin-1 is mediated by autophagy.
Morselli E, Maiuri MC, Markaki M, Megalou E, Pasparaki A, Palikaras K, Criollo A, Galluzzi L, Malik SA, Vitale I, Michaud M, Madeo F, Tavernarakis N, Kroemer G. Morselli E, et al. Among authors: megalou e. Autophagy. 2010 Jan;6(1):186-8. doi: 10.4161/auto.6.1.10817. Epub 2010 Jan 2. Autophagy. 2010. PMID: 20023410 Review.
Autophagy induction extends lifespan and reduces lipid content in response to frataxin silencing in C. elegans.
Schiavi A, Torgovnick A, Kell A, Megalou E, Castelein N, Guccini I, Marzocchella L, Gelino S, Hansen M, Malisan F, Condò I, Bei R, Rea SL, Braeckman BP, Tavernarakis N, Testi R, Ventura N. Schiavi A, et al. Among authors: megalou e. Exp Gerontol. 2013 Feb;48(2):191-201. doi: 10.1016/j.exger.2012.12.002. Epub 2012 Dec 13. Exp Gerontol. 2013. PMID: 23247094 Free PMC article.
13 results