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Discovery of a novel class of targeted kinase inhibitors that blocks protein kinase C signaling and ameliorates retinal vascular leakage in a diabetic rat model.
Grant S, Tran P, Zhang Q, Zou A, Dinh D, Jensen J, Zhou S, Kang X, Zachwieja J, Lippincott J, Liu K, Johnson SL, Scales S, Yin C, Nukui S, Stoner C, Prasanna G, Lafontaine J, Wells P, Li H. Grant S, et al. Among authors: li h. Eur J Pharmacol. 2010 Feb 10;627(1-3):16-25. doi: 10.1016/j.ejphar.2009.10.029. Epub 2009 Oct 20. Eur J Pharmacol. 2010. PMID: 19850035
Identification of novel pyrrolopyrazoles as protein kinase C β II inhibitors.
Li H, Hong Y, Nukui S, Lou J, Johnson S, Scales S, Botrous I, Tompkins E, Yin C, Zhou R, He M, Jensen J, Bouzida D, Alton G, Lafontaine J, Grant S. Li H, et al. Bioorg Med Chem Lett. 2011 Jan 1;21(1):584-7. doi: 10.1016/j.bmcl.2010.10.032. Epub 2010 Oct 13. Bioorg Med Chem Lett. 2011. PMID: 21084194
In vitro resistance study of AG-021541, a novel nonnucleoside inhibitor of the hepatitis C virus RNA-dependent RNA polymerase.
Shi ST, Herlihy KJ, Graham JP, Fuhrman SA, Doan C, Parge H, Hickey M, Gao J, Yu X, Chau F, Gonzalez J, Li H, Lewis C, Patick AK, Duggal R. Shi ST, et al. Among authors: li h. Antimicrob Agents Chemother. 2008 Feb;52(2):675-83. doi: 10.1128/AAC.00834-07. Epub 2007 Dec 10. Antimicrob Agents Chemother. 2008. PMID: 18070954 Free PMC article.
Discovery of (R)-6-cyclopentyl-6-(2-(2,6-diethylpyridin-4-yl)ethyl)-3-((5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)methyl)-4-hydroxy-5,6-dihydropyran-2-one (PF-00868554) as a potent and orally available hepatitis C virus polymerase inhibitor.
Li H, Tatlock J, Linton A, Gonzalez J, Jewell T, Patel L, Ludlum S, Drowns M, Rahavendran SV, Skor H, Hunter R, Shi ST, Herlihy KJ, Parge H, Hickey M, Yu X, Chau F, Nonomiya J, Lewis C. Li H, et al. J Med Chem. 2009 Mar 12;52(5):1255-8. doi: 10.1021/jm8014537. J Med Chem. 2009. PMID: 19209845
Preclinical characterization of PF-00868554, a potent nonnucleoside inhibitor of the hepatitis C virus RNA-dependent RNA polymerase.
Shi ST, Herlihy KJ, Graham JP, Nonomiya J, Rahavendran SV, Skor H, Irvine R, Binford S, Tatlock J, Li H, Gonzalez J, Linton A, Patick AK, Lewis C. Shi ST, et al. Among authors: li h. Antimicrob Agents Chemother. 2009 Jun;53(6):2544-52. doi: 10.1128/AAC.01599-08. Epub 2009 Mar 23. Antimicrob Agents Chemother. 2009. PMID: 19307358 Free PMC article.
Bicyclic pyrimidine compounds as potent IRAK4 inhibitors.
Chen Y, Tso K, Heckrodt TJ, Li H, Yen R, Lin N, Singh R, Taylor V, Masuda ES, Park G, Payan DG. Chen Y, et al. Among authors: li h. Bioorg Med Chem Lett. 2022 Oct 1;73:128900. doi: 10.1016/j.bmcl.2022.128900. Epub 2022 Jul 18. Bioorg Med Chem Lett. 2022. PMID: 35863718
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