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Broadly neutralizing monoclonal antibodies 2F5 and 4E10 directed against the human immunodeficiency virus type 1 gp41 membrane-proximal external region protect against mucosal challenge by simian-human immunodeficiency virus SHIVBa-L.
Hessell AJ, Rakasz EG, Tehrani DM, Huber M, Weisgrau KL, Landucci G, Forthal DN, Koff WC, Poignard P, Watkins DI, Burton DR. Hessell AJ, et al. Among authors: weisgrau kl. J Virol. 2010 Feb;84(3):1302-13. doi: 10.1128/JVI.01272-09. Epub 2009 Nov 11. J Virol. 2010. PMID: 19906907 Free PMC article.
Highly potent HIV-specific antibody neutralization in vitro translates into effective protection against mucosal SHIV challenge in vivo.
Moldt B, Rakasz EG, Schultz N, Chan-Hui PY, Swiderek K, Weisgrau KL, Piaskowski SM, Bergman Z, Watkins DI, Poignard P, Burton DR. Moldt B, et al. Among authors: weisgrau kl. Proc Natl Acad Sci U S A. 2012 Nov 13;109(46):18921-5. doi: 10.1073/pnas.1214785109. Epub 2012 Oct 25. Proc Natl Acad Sci U S A. 2012. PMID: 23100539 Free PMC article.
Subdominant CD8+ T-cell responses are involved in durable control of AIDS virus replication.
Friedrich TC, Valentine LE, Yant LJ, Rakasz EG, Piaskowski SM, Furlott JR, Weisgrau KL, Burwitz B, May GE, León EJ, Soma T, Napoe G, Capuano SV 3rd, Wilson NA, Watkins DI. Friedrich TC, et al. Among authors: weisgrau kl. J Virol. 2007 Apr;81(7):3465-76. doi: 10.1128/JVI.02392-06. Epub 2007 Jan 24. J Virol. 2007. PMID: 17251286 Free PMC article.
High viremia is associated with high levels of in vivo major histocompatibility complex class I Downregulation in rhesus macaques infected with simian immunodeficiency virus SIVmac239.
Friedrich TC, Piaskowski SM, León EJ, Furlott JR, Maness NJ, Weisgrau KL, Mac Nair CE, Weiler AM, Loffredo JT, Reynolds MR, Williams KY, Klimentidis YC, Wilson NA, Allison DB, Rakasz EG. Friedrich TC, et al. Among authors: weisgrau kl. J Virol. 2010 May;84(10):5443-7. doi: 10.1128/JVI.02452-09. Epub 2010 Mar 10. J Virol. 2010. PMID: 20219903 Free PMC article.
Ex vivo analysis of SIV-infected cells by flow cytometry.
Reynolds MR, Piaskowski SM, Weisgrau KL, Weiler AM, Friedrich TC, Rakasz EG. Reynolds MR, et al. Among authors: weisgrau kl. Cytometry A. 2010 Nov;77(11):1059-66. doi: 10.1002/cyto.a.20960. Cytometry A. 2010. PMID: 20722008 Free PMC article.
AAV-delivered eCD4-Ig protects rhesus macaques from high-dose SIVmac239 challenges.
Gardner MR, Fellinger CH, Kattenhorn LM, Davis-Gardner ME, Weber JA, Alfant B, Zhou AS, Prasad NR, Kondur HR, Newton WA, Weisgrau KL, Rakasz EG, Lifson JD, Gao G, Schultz-Darken N, Farzan M. Gardner MR, et al. Among authors: weisgrau kl. Sci Transl Med. 2019 Jul 24;11(502):eaau5409. doi: 10.1126/scitranslmed.aau5409. Sci Transl Med. 2019. PMID: 31341061 Free PMC article.
A strategy for high antibody expression with low anti-drug antibodies using AAV9 vectors.
Davis-Gardner ME, Weber JA, Xie J, Pekrun K, Alexander EA, Weisgrau KL, Furlott JR, Rakasz EG, Kay MA, Gao G, Farzan M, Gardner MR. Davis-Gardner ME, et al. Among authors: weisgrau kl. Front Immunol. 2023 Apr 21;14:1105617. doi: 10.3389/fimmu.2023.1105617. eCollection 2023. Front Immunol. 2023. PMID: 37153616 Free PMC article.
Molecular insights into antibody-mediated protection against the prototypic simian immunodeficiency virus.
Zhao F, Berndsen ZT, Pedreño-Lopez N, Burns A, Allen JD, Barman S, Lee WH, Chakraborty S, Gnanakaran S, Sewall LM, Ozorowski G, Limbo O, Song G, Yong P, Callaghan S, Coppola J, Weisgrau KL, Lifson JD, Nedellec R, Voigt TB, Laurino F, Louw J, Rosen BC, Ricciardi M, Crispin M, Desrosiers RC, Rakasz EG, Watkins DI, Andrabi R, Ward AB, Burton DR, Sok D. Zhao F, et al. Among authors: weisgrau kl. Nat Commun. 2022 Sep 6;13(1):5236. doi: 10.1038/s41467-022-32783-2. Nat Commun. 2022. PMID: 36068229 Free PMC article.
38 results