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Introduction of virulence markers in PB2 of pandemic swine-origin influenza virus does not result in enhanced virulence or transmission.
Herfst S, Chutinimitkul S, Ye J, de Wit E, Munster VJ, Schrauwen EJ, Bestebroer TM, Jonges M, Meijer A, Koopmans M, Rimmelzwaan GF, Osterhaus AD, Perez DR, Fouchier RA. Herfst S, et al. Among authors: ye j. J Virol. 2010 Apr;84(8):3752-8. doi: 10.1128/JVI.02634-09. Epub 2010 Feb 3. J Virol. 2010. PMID: 20130063 Free PMC article.
Virulence-associated substitution D222G in the hemagglutinin of 2009 pandemic influenza A(H1N1) virus affects receptor binding.
Chutinimitkul S, Herfst S, Steel J, Lowen AC, Ye J, van Riel D, Schrauwen EJ, Bestebroer TM, Koel B, Burke DF, Sutherland-Cash KH, Whittleston CS, Russell CA, Wales DJ, Smith DJ, Jonges M, Meijer A, Koopmans M, Rimmelzwaan GF, Kuiken T, Osterhaus AD, García-Sastre A, Perez DR, Fouchier RA. Chutinimitkul S, et al. Among authors: ye j. J Virol. 2010 Nov;84(22):11802-13. doi: 10.1128/JVI.01136-10. Epub 2010 Sep 15. J Virol. 2010. PMID: 20844044 Free PMC article.
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