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Fifth complement cascade protein (C5) cleavage fragments disrupt the SDF-1/CXCR4 axis: further evidence that innate immunity orchestrates the mobilization of hematopoietic stem/progenitor cells.
Jalili A, Shirvaikar N, Marquez-Curtis L, Qiu Y, Korol C, Lee H, Turner AR, Ratajczak MZ, Janowska-Wieczorek A. Jalili A, et al. Among authors: lee h. Exp Hematol. 2010 Apr;38(4):321-32. doi: 10.1016/j.exphem.2010.02.002. Epub 2010 Feb 12. Exp Hematol. 2010. PMID: 20153802 Free PMC article.
Novel insight into stem cell mobilization-plasma sphingosine-1-phosphate is a major chemoattractant that directs the egress of hematopoietic stem progenitor cells from the bone marrow and its level in peripheral blood increases during mobilization due to activation of complement cascade/membrane attack complex.
Ratajczak MZ, Lee H, Wysoczynski M, Wan W, Marlicz W, Laughlin MJ, Kucia M, Janowska-Wieczorek A, Ratajczak J. Ratajczak MZ, et al. Among authors: lee h. Leukemia. 2010 May;24(5):976-85. doi: 10.1038/leu.2010.53. Epub 2010 Apr 1. Leukemia. 2010. PMID: 20357827 Free PMC article.
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