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Applying genomics in regulatory toxicology: a report of the ECETOC workshop on omics threshold on non-adversity.
Gant TW, Auerbach SS, Von Bergen M, Bouhifd M, Botham PA, Caiment F, Currie RA, Harrill J, Johnson K, Li D, Rouquie D, van Ravenzwaay B, Sistare F, Tralau T, Viant MR, van de Laan JW, Yauk C. Gant TW, et al. Arch Toxicol. 2023 Aug;97(8):2291-2302. doi: 10.1007/s00204-023-03522-3. Epub 2023 Jun 9. Arch Toxicol. 2023. PMID: 37296313 Free PMC article.
Towards best use and regulatory acceptance of generic physiologically based kinetic (PBK) models for in vitro-to-in vivo extrapolation (IVIVE) in chemical risk assessment.
Najjar A, Punt A, Wambaugh J, Paini A, Ellison C, Fragki S, Bianchi E, Zhang F, Westerhout J, Mueller D, Li H, Shi Q, Gant TW, Botham P, Bars R, Piersma A, van Ravenzwaay B, Kramer NI. Najjar A, et al. Among authors: gant tw. Arch Toxicol. 2022 Dec;96(12):3407-3419. doi: 10.1007/s00204-022-03356-5. Epub 2022 Sep 5. Arch Toxicol. 2022. PMID: 36063173 Free PMC article.
Reactive Oxygen Species in the Adverse Outcome Pathway Framework: Toward Creation of Harmonized Consensus Key Events.
Tanabe S, O'Brien J, Tollefsen KE, Kim Y, Chauhan V, Yauk C, Huliganga E, Rudel RA, Kay JE, Helm JS, Beaton D, Filipovska J, Sovadinova I, Garcia-Reyero N, Mally A, Poulsen SS, Delrue N, Fritsche E, Luettich K, La Rocca C, Yepiskoposyan H, Klose J, Danielsen PH, Esterhuizen M, Jacobsen NR, Vogel U, Gant TW, Choi I, FitzGerald R. Tanabe S, et al. Among authors: gant tw. Front Toxicol. 2022 Jul 6;4:887135. doi: 10.3389/ftox.2022.887135. eCollection 2022. Front Toxicol. 2022. PMID: 35875696 Free PMC article. Review.
R-ODAF: Omics data analysis framework for regulatory application.
Verheijen MC, Meier MJ, Asensio JO, Gant TW, Tong W, Yauk CL, Caiment F. Verheijen MC, et al. Among authors: gant tw. Regul Toxicol Pharmacol. 2022 Jun;131:105143. doi: 10.1016/j.yrtph.2022.105143. Epub 2022 Mar 3. Regul Toxicol Pharmacol. 2022. PMID: 35247516 Free article.
113 results