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In a randomized, double-blinded, placebo-controlled trial, the single oral dose typhoid vaccine, M01ZH09, is safe and immunogenic at doses up to 1.7 x 10(10) colony-forming units.
Lyon CE, Sadigh KS, Carmolli MP, Harro C, Sheldon E, Lindow JC, Larsson CJ, Martinez T, Feller A, Ventrone CH, Sack DA, DeNearing B, Fingar A, Pierce K, Dill EA, Schwartz HI, Beardsworth EE, Kilonzo B, May JP, Lam W, Upton A, Budhram R, Kirkpatrick BD. Lyon CE, et al. Among authors: kirkpatrick bd. Vaccine. 2010 Apr 30;28(20):3602-8. doi: 10.1016/j.vaccine.2010.02.017. Epub 2010 Feb 24. Vaccine. 2010. PMID: 20188175 Clinical Trial.
Evaluation of Salmonella enterica serovar Typhi (Ty2 aroC-ssaV-) M01ZH09, with a defined mutation in the Salmonella pathogenicity island 2, as a live, oral typhoid vaccine in human volunteers.
Kirkpatrick BD, McKenzie R, O'Neill JP, Larsson CJ, Bourgeois AL, Shimko J, Bentley M, Makin J, Chatfield S, Hindle Z, Fidler C, Robinson BE, Ventrone CH, Bansal N, Carpenter CM, Kutzko D, Hamlet S, LaPointe C, Taylor DN. Kirkpatrick BD, et al. Vaccine. 2006 Jan 12;24(2):116-23. doi: 10.1016/j.vaccine.2005.08.008. Epub 2005 Aug 18. Vaccine. 2006. PMID: 16140433 Clinical Trial.
Comparison of the antibodies in lymphocyte supernatant and antibody-secreting cell assays for measuring intestinal mucosal immune response to a novel oral typhoid vaccine (M01ZH09).
Kirkpatrick BD, Bentley MD, Thern AM, Larsson CJ, Ventrone C, Sreenivasan MV, Bourgeois L. Kirkpatrick BD, et al. Clin Diagn Lab Immunol. 2005 Sep;12(9):1127-9. doi: 10.1128/CDLI.12.9.1127-1129.2005. Clin Diagn Lab Immunol. 2005. PMID: 16148184 Free PMC article. Clinical Trial.
Update on human infections caused by intestinal protozoa.
Pierce KK, Kirkpatrick BD. Pierce KK, et al. Among authors: kirkpatrick bd. Curr Opin Gastroenterol. 2009 Jan;25(1):12-7. doi: 10.1097/mog.0b013e32831da7dd. Curr Opin Gastroenterol. 2009. PMID: 19119509
Campylobacter jejuni strain CG8421: a refined model for the study of Campylobacteriosis and evaluation of Campylobacter vaccines in human subjects.
Tribble DR, Baqar S, Carmolli MP, Porter C, Pierce KK, Sadigh K, Guerry P, Larsson CJ, Rockabrand D, Ventone CH, Poly F, Lyon CE, Dakdouk S, Fingar A, Gilliland T, Daunais P, Jones E, Rymarchyk S, Huston C, Darsley M, Kirkpatrick BD. Tribble DR, et al. Among authors: kirkpatrick bd. Clin Infect Dis. 2009 Nov 15;49(10):1512-9. doi: 10.1086/644622. Clin Infect Dis. 2009. PMID: 19842970 Clinical Trial.
126 results