Kawabata K - Search Results

1

ONO-5046, a novel inhibitor of human neutrophil elastase.

Kawabata K, Suzuki M, Sugitani M, Imaki K, Toda M, Miyamoto T. Kawabata K, et al. Biochem Biophys Res Commun. 1991 Jun 14;177(2):814-20. doi: 10.1016/0006-291x(91)91862-7. Biochem Biophys Res Commun. 1991. PMID: 2049103

2

Effects of ONO-5334, a novel orally-active inhibitor of cathepsin K, on bone metabolism.

Ochi Y, Yamada H, Mori H, Nakanishi Y, Nishikawa S, Kayasuga R, Kawada N, Kunishige A, Hashimoto Y, Tanaka M, Sugitani M, Kawabata K. Ochi Y, et al. Among authors: kawabata k. Bone. 2011 Dec;49(6):1351-6. doi: 10.1016/j.bone.2011.09.041. Epub 2011 Sep 18. Bone. 2011. PMID: 21982869

3

Design and synthesis of new orally active inhibitors of human neutrophil elastase.

Ohmoto K, Okuma M, Yamamoto T, Kijima H, Sekioka T, Kitagawa K, Yamamoto S, Tanaka K, Kawabata K, Sakata A, Imawaka H, Nakai H, Toda M. Ohmoto K, et al. Among authors: kawabata k. Bioorg Med Chem. 2001 May;9(5):1307-23. doi: 10.1016/s0968-0896(01)00007-4. Bioorg Med Chem. 2001. PMID: 11377188

4

Effects of eight-month treatment with ONO-5334, a cathepsin K inhibitor, on bone metabolism, strength and microstructure in ovariectomized cynomolgus monkeys.

Ochi Y, Yamada H, Mori H, Nakanishi Y, Nishikawa S, Kayasuga R, Kawada N, Kunishige A, Hashimoto Y, Tanaka M, Sugitani M, Kawabata K. Ochi Y, et al. Among authors: kawabata k. Bone. 2014 Aug;65:1-8. doi: 10.1016/j.bone.2014.04.023. Epub 2014 Apr 27. Bone. 2014. PMID: 24784023

5

Development of orally active nonpeptidic inhibitors of human neutrophil elastase.

Ohmoto K, Yamamoto T, Okuma M, Horiuchi T, Imanishi H, Odagaki Y, Kawabata K, Sekioka T, Hirota Y, Matsuoka S, Nakai H, Toda M, Cheronis JC, Spruce LW, Gyorkos A, Wieczorek M. Ohmoto K, et al. Among authors: kawabata k. J Med Chem. 2001 Apr 12;44(8):1268-85. doi: 10.1021/jm000410y. J Med Chem. 2001. PMID: 11312926

6

Inhibition of neutrophil elastase activity attenuates complement-mediated lung injury in the hamster.

Hagio T, Nakao S, Matsuoka H, Matsumoto S, Kawabata K, Ohno H. Hagio T, et al. Among authors: kawabata k. Eur J Pharmacol. 2001 Aug 24;426(1-2):131-8. doi: 10.1016/s0014-2999(01)01191-8. Eur J Pharmacol. 2001. PMID: 11525781

7

Discovery of long-acting N-(cyanomethyl)-N-alkyl-L-prolinamide inhibitors of dipeptidyl peptidase IV.

Kondo T, Nekado T, Sugimoto I, Ochi K, Takai S, Kinoshita A, Hatayama A, Yamamoto S, Kawabata K, Nakai H, Toda M. Kondo T, et al. Among authors: kawabata k. Bioorg Med Chem. 2008 Jan 1;16(1):190-208. doi: 10.1016/j.bmc.2007.10.005. Epub 2007 Oct 5. Bioorg Med Chem. 2008. PMID: 17962025

8

[Pharmacological profile of a specific neutrophil elastase inhibitor, Sivelestat sodium hydrate].

Kawabata K, Hagio T, Matsuoka S. Kawabata K, et al. Nihon Yakurigaku Zasshi. 2003 Aug;122(2):151-60. doi: 10.1254/fpj.122.151. Nihon Yakurigaku Zasshi. 2003. PMID: 12890901 Review. Japanese.

9

Inhibition of neutrophil elastase reduces lung injury and bacterial count in hamsters.

Hagio T, Kishikawa K, Kawabata K, Tasaka S, Hashimoto S, Hasegawa N, Ishizaka A. Hagio T, et al. Among authors: kawabata k. Pulm Pharmacol Ther. 2008 Dec;21(6):884-91. doi: 10.1016/j.pupt.2008.10.002. Epub 2008 Oct 17. Pulm Pharmacol Ther. 2008. PMID: 18992355

10

Delayed neutrophil elastase inhibition prevents subsequent progression of acute lung injury induced by endotoxin inhalation in hamsters.

Kawabata K, Hagio T, Matsumoto S, Nakao S, Orita S, Aze Y, Ohno H. Kawabata K, et al. Am J Respir Crit Care Med. 2000 Jun;161(6):2013-8. doi: 10.1164/ajrccm.161.6.9904047. Am J Respir Crit Care Med. 2000. PMID: 10852782

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